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I like the concept of Hy, but has anyone used it for something "serious"?

In other words, apart from parenthetical syntax, what value does it add over just writing Python? For example, what macros are useful "in the wild"?

The canonical example of macro that is useful "in the wild" is embedding SQL in your code. See for example http://www.gigamonkeys.com/book/practical-an-mp3-database.ht...

(Disclosure: I am just an occasional LISP dabbler)