What helped? Using a debugger and stepping through the code was useful, it's more a less a REST-API here (build ontop of the system, before it was SOAP, etc.pp) and I've just used some heavily used endpoints and stepped through all the way...
Another huge boost in understanding was using flamegraphs (not sure what's hip for nodejs maybe this? https://github.com/davidmarkclements/0x)
This was really an eye opener because that app also used an external huge Java ECM and there was lot's of AOP magic, reading the flamegraphs and looking at the source was a big boost in understanding.
It's also a really useful tool to get visibility for performance problems that are not directly visible in the code.
If there are tests, reading them might also be worthwile.
And take your time... took me a few months to get a basic understanding how it's working (I'm more sysadmin, not really a dev there), so don't except to grasp everything in one week.
Ask your colleagues - maybe were to find documentation or if you don't understand something while reading the source.