- Removes all DNS leak privacy issues, for all Firefox users, automatically
- Removes all possibility for a MitM to view or corrupt DNS queries or responses, for all Firefox users, automatically
And Cloudflare claims to delete all DNS-related logs of Firefox users within 24 hours: https://developers.cloudflare.com/1.1.1.1/commitment-to-priv...
Even if you distrust Cloudflare or think they're not secure against breaches, it's still a massive security and privacy upgrade over using your ISP's DNS servers, which will pretty much always leak sensitive information about your connection (potentially leading to deanonymization while using an anonymizing service) and send/receive everything in unauthenticated plaintext.
And in addition, your ISP likely is less trustworthy and less secure against breaches (even if you aren't using Comcast, Verizon, or AT&T) than Cloudflare. But again, even if you don't trust them, this would still be the best move for security.
Plus it's a big latency decrease and performance boost for most or all users.