Is there anything in umatrix to make the switch worthwhile?
That's a lot of configuration to do. I'd rather just use Firefox containers, noscript, and use Tor for things I don't want tied to my ad profile.
It's not a lot of config at all. If the site breaks, you click a button and unblock some stuff. Otherwise the defaults work great.
For the ones that don't work it's normally 1 or 2 clicks in the UI to allow some 3rd parties and save it.
Sometimes a site works by default in the "broken" state but as soon as I give it more permissions it breaks by adding a paywall or some modal window.
uMatrix is like linux: it requires more work upfront but give you more control and customization options.