As a minimal and extremely non-scientific benchmark, I've constructed a simple fixed data structure that encodes to JSON (using Python `json` module) and simple binary formats (that would be an ideal case for Python `struct` module). Decoding the same simple value 1,000,000 times in CPython 3.6.4 took...
Format Size Iters. Speed
------ ---- --------- ----------
JSON 28 205,000 5.75 MB/s
Struct 6 2,400,000 14.4 MB/s
Of course YMMV, but even the `struct` module was only 2--12 times (depending on what you care about) faster than the `json` module in this particular case. And this is really minimal, you need an (slow) interpreted code for more complex binary formats. Right, you can use PyPy for the JIT compilation or binary modules for sidestepping the interpreter overhead! The point is that, it of course matters, but not quite drastic improvements you'd imagine.