On topic: I've experienced exactly what he's talking about in the field of indie game development. The entire gamedev industry is on Twitter. It was an endless treadmill of validation seeking for me. At first it's screaming into the void, then it's strategically following and unfollowing people, then eventually it's one mega tweet that gets retweeted by your childhood hero or one of the cool indie illuminati kids. It's never enough and you're never happy.
There's a super indie hip event in LA called IndieCade that I've probably spent $250 in application fees over the years trying to get my game into. I was devastated every time I got rejected. A couple months ago I got tickets for free, and coming from a fresh perspective outside the industry, it was shockingly underwhelming. There was a dad with 13-year-old daughters showing off a painfully amateur interactive fiction they wrote as a family. I couldn't believe THIS was the thing I had cared about so much.
Whatever industry bubble you're in... it's not that important and no one outside the bubble cares. And when I realized that, it felt like a huge burden lifted. :)