Ask HN: Best Tool for Creating Binary Running in Windows Enterprise Environment?

I'm helping a friend with an enormous Excel+VBA solution that reads an input excel sheet and outputs numerous sheets with calculated values (think like a time report or something).

I've been thinking about some way to do this in a more sane programming language. The logic itself is simple, and I could probably write 100 lines of Python to replace the whole thing, with openpyxl for creating new sheets.

There's no need to use Excel+VBA except that anyone can run it, i.e no one except my friend need to inspect/modify the code.

However, the end users are in a (I'm guessing) pretty locked down Windows environment and my Windows skills are severely lacking.

Can I use something like py2exe and have end users running the binaries in a normal Windows enterprise settings, include reading and modifying files in the folder where the exe is running? If not, is there something else, besides the current solution that is resonable?