So might the risk of harpooning one big thing have a net negative effect by creating more tiny objects?
Also, depending on the orbit considered, the debris generated by the harpoon may be less harmful: they have typically a high surface area/weight ratio so they will deorbit fast if the altitude is low enough, like for this mission.
Other than removed selected really large pieces, such as entire derelict spacecraft, in crowded orbits like GEO where the likelihood of hitting something else is high.