Just wanted to mention there's some folks doing realtime source separation (not sure exactly how they've implemented it) with a DNN for reduction of background noise in, eg: Skype conversations.
I'm not involved with them in any way, but I've been amazed with its ability to cancel out coffee-shop style noise.
Check out https://krisp.ai/technology/ - Mac/Windows. I wish they had Linux support!
Edit: Appears they don't have Windows support yet.