I liked Stephen Wolframs ideas around cellular automata and network based structures -- it seems that if we could look at physics as more of an information transfer problem -- paired with network optimization and information storage optimization, on a network: this is where real progress will be made. There have been theories around emergent spacetime from thermodynamic processes that were abandoned and IMO need to be re-investigated.
I highly doubt that wave function collapse is just completely random. We just don't see the structure that is creating the "random" distributions we observe.