Yes, 20% of sites I load are either a blank page or "You need to enable JavaScript to run this app" (it's the new "An error has occurred"). If it's a friend's site, or something that obviously needs it - like a game, or art project - then I'll temporarily whitelist it. But if not, then hey, I just got a 20% productivity boost by saving some time on whatever it is that thinks it needs JavaScript!
I used uMatrix myself in the past (I also used NoScript a much longer while ago), but it requires too much time to cherry pick the remote hosts (usually CDNs) and files to allow.
I browse with no javascript a large proportion of the time.
The web is so refreshingly fast without all the scripts.
aside: used to use/implement something like ajax callbacks with hidden frames and dynamic form posts.
Man, I love JS/Browsers today over pre-2016.