Having to micromanage what you do so you don't burn in the screen seems like an endless source of anxiety for someone like me. No thank you.
There'd be some details to work out, like making sure you don't trigger word wrap changes. One approach would be to leave a little border on at least one of the screen, so you can move everything together horizontally without changing window widths. In the vertical direction maybe you can get away with changing relative window sizes slightly.
(On the other hand, if you're mainly using text in dark mode, maybe your fancy OLED screen isn't benefiting you much.)