Scientists are transplanting faeces into obese people with type 2 diabetes
walesonline.co.uk
walesonline.co.uk
“It’s in liquid form and injected through a tube in the patient’s nose. There is no smell or taste associated with it – it’s all very purified.”
Fecal Microbiota Transplantation for Clostridium difficile Infection: A Systematic Review - https://annals.org/aim/article-abstract/2288521/fecal-microb...
I just cribbed these from the Wikipedia article at https://en.wikipedia.org/wiki/Clostridioides_difficile_infec... so I don't know if there's better or more recent studies.
The Mayo Clinic has posted numbers for a couple of different clinic locations that have seen a a 90% success rate.
https://www.mayoclinic.org/medical-professionals/digestive-d...
It doesn't seem to be working.
Yet the most educated societies have the worst problems with obesity. A fair statistical case could be made that Education causes obesity, albeit it too would miss most of the problem.
>reason of high calorie intake is not gut bacteria [majority of cases]
Most research I've read, especially around epigenetics, the thrifty metabolism and the Dutch hunger winter studies, all show a strikingly different biome of gut bacteria in [an overwhelming majority] of obese individuals compared to average bmi non-thrifty metabolic people.
I'm curious if these folks tried to lower sugar intake in all forms and reduce their eating window to 8 hours and whether that would have lowered Insulin Production and caused an increase in Insulin sensitivity.
How difficult it is for people to change lifestyle habits to fix their hormonal unbalance when it comes to obesity.
Sadly, evidently, very.
Annecdotally, most ppl don't seem to connect what they consume with their health. There's no sense of garbage in...feel like garbage.
I'm not sure what they're tbinking but when I look at their bodies and then at their shopping cart (at the super market) disconnect wins 9 of 10 times.
Furthermore, abnormal has been normalized. Humans are naturally wired to assume the norm. They see what's around them and naturally presume it's okay. Obesity is the new black. Soda, cookies, etc. (and the advertisement there of) is ubiquitous. Honesty is now called "fat shaming."
I understand there are people who have health issue the cause them to be obese. The rest a simply negligent. Sadly, it's not PC to say such truths.
p.s. Editorial: How is it, in the face of the obesity crisis (which directly contributes to increased healthcare costs), that the adults who lead the Girl Scouts are still pushing cookies. The hypocrisy and absurdity boggles my mind.
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Speaking as an obese person that knows the dangers and generally does the right thing re: diet and excercise- it’s crazy hard.
I entered freshman year of HS 6’2” 275lb, graduated Senior year 6’3” 290lb. I’m 36 now and my weight has pretty much been in that same window my entire life.
I played very high level high school athletics (4 sport varsity, all star teams, etc.), still play competitive “A” league rec sports all year every year, and still do cardio and weight lifting 3-5 days a week. I hike at least 6 miles a week rain or shine with my bow and hunting pack in the woods outside my house for practice. I’m very strong and shockingly flexible- but I still have the physique of a beer league bowler (of which I also am).
I don’t drink soda or eat fast food for the most part, and my diet throughout the week is mostly veggies and proteins. My diet is definitely not perfect and I must be consistently eating more than I output, but...
The weight will melt away until I get to 275 and then my body turns into an always hungry eating machine. Or If I have pizza (or something carby) for lunch I’ll be craving carb food the rest of the day.
My will power is strong, but there is no such thing as just one bite. It’s zero bites or all the bites and it’s a crazy pull. It’s also infuriating because this is the one part in my life where I’ve never been able to just will it so. Sports, work, kids, outdoor adventuring: I have never faced a situation that I couldn’t just grit my teeth and make it through.
Not the weight though. There are too many little unconscious failures that stack up through a day or week that will hinder progress. The conscious ones take a toll even more because now you get to think about “I shouldn’t have...” the rest of the day.
It’s a weird deal, luckily it doesn’t take an emotional toll on me like I’ve heard it takes others. It’s a thing, it’s my thing I try and work on (that and being generally nicer), I just keep plugging and monitor the hell out of my health. BP, glucose, A1C, cholesterols, etc. all paint a picture of a man healthier than I look on a BMI chart.
I still got stuck at my old normal, but it’s now easy to maintain. Maintain that for a year or so and you can start cutting things again without awakening that ravenous hunger.
So what if you only lose 40 lb in 4 years that’s still real and sustainable progress. At 38 it’s the end of January and even with plenty of indulgence I weigh what I did before thanksgiving, that’s huge IMO.
PS: I am still heavy, but dropping your BMI by 5+ and keeping it off while also bulking up just feels so much better. Remember, a net gain or loss of even 1 pound per year adds up.
Personal will-power aide, it's hard because so much of the things that are designed to work against you have been normalized. Sadly, no one wants to hear - because of the way humans are wired - that their personal decisions have (literally) bigger and broader social implications.
Big might be beautiful. Thanks Oprah! But it's also unhealthy. Funny how that's never mentioned. It's madness how a parent can get arrested for leaving their child home alone (or similar) but it's perfectly fine to raise a 10 y/o to be obese, bordering on T2D.
p.s. Kudos to you for making the effort. I know it's not easy, as mentioned. What kills me is the denial of how normalized abnormal has become. And saying so in any form is not PC.
somewhat familiar. Finding oneself deep at night in the kitchen eating donuts/cake/pastries/cookies/pizza/waffles/etc. and not able to stop... I'm 6' and topped at 230 soon after coming to the US (that supermarket quick-rise white bread is easily half of US medical problems). By starting to exercise regularly i took it under some control and had been keeping it between 180-200 since then. A year ago a GE using breath test diagnosed me with pretty severe SIBO. Once i was able to take SIBO under control (separate story as typical antibiotic treatment didn't work (happens in 30-70% cases according to various sources)) those sugary&fat cravings got much easier - that is inline with the growing body of research about chemical signaling, including neurochemicals, these gut bacteria do (and they love sugars and high blood glucose level). Resisting such a direct injection of neurochemicals is a pretty uphill battle, and it is no surprise that a lot, if not majority, of people aren't able to.
Yeah, that's more about the fact that if you're telling someone who's fat that they're fat, guess what - they already know, and they're probably already very conscious about it.
"shaming" people for it will either make it worse for them or inspire change; but if they're in that situation it trends towards worse.
It's no help at all, and a bit of a dick move at best.
If people choose to let themselves go, I'm not so sure another pat on the back is the answer.
To me it looks like the rise in obesity could roughly map to the rise in depression and anxiety, though I have no data on that and I make no assertions on the causality, should they turn out to be correlated.
I comment every time I see the obesity/calories topic come up because it's something I've been deeply researching and experimenting with for years and I can't let misconceptions and falsehoods go without a response.
To avoid letting this get into a lengthy back-and-forth, I'll just state what I understand and move on.
Yes, food/calorie intake and expenditure is partly a choice, but it is a choice that is profoundly complicated by many factors, including but not limited to: diagnosed or undiagnosed illness, pre-exisiting nutritional levels, genetics/epigenetic expression, emotions/hormones/neurological issues, social influence, culture, financial constraints, time constraints and more.
Obviously, letting one's self go is not something that most people freely choose to do or enjoy doing.
Some work harder than others to avoid it. Some succeed, and some fail even if they work hard at it.
Usually when I get into a back-and-forth discussion about this topic, the co-debater will resort to something like "I don't have all the answers but everyone can try harder to cut calories".
We'd all be better off if people simply stuck to the shorter, humbler version: "I don't have the answers."
Anyone who does have answers could contact their nearest metabolic research institution.
Who's going to tell you where the good foods are at, that have not been tampered with, and that are compatible with your body, vs the bad foods?
Who's going to train you to cook?
Who'se going to help you with your mental health? As far back as the 1800's Mormons running insane asylums knew fixing diet resolved mental health issues 50% of the time. Most obesity, especially people hundreds of pounds overweight, are due to mental health problems.
And finally, if you're over the tipping point of these problems, how do you overcome them? A Diet for a 500ib person losing weight has to be engineered very differently than someone who's 200ibs looking to lose 10 pounds of belly fat.
This is a complex subject, with an obecity epidemic, you should be asking the questions of "Who poisoned these people?" and also "Do we have a mental health crisis?". Follow those questions to their root and you'll find most of the answer.
"Oh, but an occasional bottle of pop [soda, sugar-y fizzy drink] is fine", for sure, but $BRAND aren't advertising to get you to have one of their drinks each month; they want you to reach for 3-a-day. [Mind you the major pop brands have modified their behaviour, removing regular sugars and pushing sweetener; I think they're worming their way out of being sued like the tobacco companies were. And there's good and bad in that.]
For instance, surgery that removes the upper portion of the small intestine has a large observed effect.
>gastrointestinal surgery can improve blood-sugar levels more effectively than any lifestyle or pharmaceutical intervention, and even lead to long-term remission of the disease.
https://www.scientificamerican.com/article/why-doctors-for-d...
We know it works, but don't know why.
Very recently, doctors released a study showing that just destroying the inner mucous membrane in that region of the small intestine had a similar effect.
>By destroying the mucous membrane in the small intestine and causing a new one to develop, scientists stabilised the blood sugar levels of people with type 2 diabetes. The results have been described as “spectacular” – albeit unexpected – by the chief researchers involved.
Even a year after the treatment, the disease was found to be stable in 90% of those treated.
https://www.theguardian.com/society/2018/oct/24/spectacular-...
This early study of a much less invasive treatment certainly deserves further study.
It's not going into the nose, it's going into the jejunum (the intestines) via a nasojejunal tube, which is placed up your nose.
1. Fecal transplants are pseudoscience, because we don't know if they work.
2. We should assume they work, and identify specific microbes within them that are relevant or dangerous.
That's contradictory. Further, without data from examining #1, #2 is almost impossible - there are at least 1,000 species in our gut at all times. The only identification process I know of that could be reasonably affordable is 16S RNA sequencing, which is still expensive and would be nearly impossible to do properly on the 0.5 - 1.0 kg sample of gut bacteria (yes, that's the weight of just bacteria) from the average human. Not to mention that evidence suggests that gut bacteria act in concert, that is, we'd have to examine combinatorially many combinations of these 1,000+ species to get any real data.
This is just nonsense.