I gave this a try, but sadly it came up short. For writing a single paper of MSc Thesis, it might work. However it just doesn't seem suited for handling a large number of references for a variety of projects, which get called on frequently as standard references in papers, reference material, and much more.

If it helps I have just under 2000 papers in my Zotero. It isn't massive by research standards, but it is substantial.