Yes, and these aren't that easy to manage, but still doable, but thanks to a really helpful and big community it's easier. Some tools allow for regex, wildcards and similar.

The bigger issue comes from the likes of Google/YouTube/Facebook who host their ads on the same domain as their main website, ergo, if you want to block the ad domains, you'll be blocked the main domains as a whole. In this case, the only way to block ads is through an in-browser addon.

You might be interested in this ticket: Encrypted subdomains for routing ads https://github.com/StevenBlack/hosts/issues/801

A PiHole could do wildcard blocking for the subdomain - but as in the ticket where the content for the site is also served from the same encrypted subdomains - nothing can be done. uBlock origin filters also fail at blocking these requests. After some research, I found a potential solution is to block off of request headers, since the ad tool is using headers as a way to send data. Unfortunately I'm unaware of any browser based tool that is able to block requests based on header content.

Its very interesting that this encrypted subdomain tool is only enabled in chrome and not Firefox. It will also detect if the developer tools are open or not. WebMD is a good example where this tool is being used.