I wish there were a more user-friendly way for people to use it, without the command-line and winetricks. I use wine on macOS, but I usually hesitate before diving in, because I know it inevitably involves some gymnastics. Even with Wineskin Winery (which is no longer maintained?).
Will WINE ever be at a point where it would be stable enough to make the case for non-technical users? Another comment joked about public offices -- would it be absurd to think offices could run linux instead of windows, saving licensing costs, using WINE where legacy software is necessary?
I would have started using WINE even earlier if the documentation were more approachable. I think they've improved over the last few years, though the site still looks like an antique forum system rather than cutting-edge tech + design, like you would see from a startup's website.