I've read somewhere that driverless trucks are pretty much as hard as driverless anything, because there's always that last mile in a city. It's impossible for the ride to be 100% automated, and anything less is pointless at the moment.
I think we'll need some extremely standardized "pre-last-mile" highway exits/transfer points across the whole country to have the beginnings of a new solution. And I doubt the Teamsters will be onboard with that.