Guix is also working on an installer to help reducing the friction. I'd personally like to work on a fully graphical install + package management.
While Guix sounds like some heavy scientific stuff, it really is a powerful base that allows anything to grow on top, including user-friendly interfaces.
The biggest thing that might be annoying for someone who is not comfortable with Lisp is probably the operating system configuration, which is done with Scheme. For installing packages, however, you can use the command line interface, or the convenient Emacs user interface --- neither of those require any programming knowledge.