The license can be a problem for some studios, specially ones with uncomfortable contracts with publishers. If you are in that situation, I highly recommend writing a LuaJIT integration layer.

The game code is very well separated from the engine, and qengine already removes a lot of non-generic game code from Q2. So all you have to do is delete a little bit more, write some glue code to tie in Lua, and you can write the entire game logic in a separate codebase, with a separate license. Also, you get moddability.