How about when it's not a simple underlying problem ("hands get dry in cold climate")? A speech impediment which is cute in a small kid but weird in middle school and socially+career-limiting in an adult. Or an aggression issue. Or one of the many spectrum issues, which won't go away by moving to a warmer climate.
Author here.
I had all of those issues. Both my sons are Twice Exceptional. One has a bad temper and is prone to violence. They both likely qualify as ASD. One had a serious speech impediment. He still has a speech impediment, but most people don't realize it.
All of those were easier to deal with because my kids trusted me. Trust was absolutely critical for resolving the hardest problems.
It's one post, so it's not going to answer everything. Hopefully, things will get fleshed out over time in a useful way for parents with such concerns, assuming I can get engagement and also find time to do this kind of writing instead of freelance writing to keep the lights on and food on the table.