Hacker News Reader

Comment by bdamm | Hacker News Reader

Unclear. I have close family that is having marked and unprecedented success in treating serious depression by microdosing psilocybin below the psychedelic threshold. The result is profound, sustained, and after trying a dozen different approved psychiatrist prescribed drugs to find help can not be a placebo effect as surely any of those would have been just as effective.

View on HN

Out of curiosity, have they tried macro-dosing to be ineffective?

Ie instead of ongoing microdosing, having a 2-3g experience once or twice.

I have very little faith in main stream psychiatric care to provide anything other than blunt palliative options (often with lethal conseuences).

They have not yet, because we haven't found a way to provide a safe environment for this person to be in that can be sustained long enough to cover the entire experience. Providing safety would include alleviating their responsibilities, which includes child care, so that gets pretty complex.

Understood. Wishing you an afternoon and the support needed soon.

Also really glad you have found relief with microdosing!

There isn't a clear threshold in regards to microdosing. You're still getting the psychedelic effect from the psilocybin, just proportionally less.

It's uncertain if microdosing a particular ligand has any scientifically-proven evidence of efficacy without studying it. In many instances, it maybe a shared delusion placebo effect and/or socially-reinforced fad.

If your state of consciousness is altered by 2% that's just called a normal day.

There is a very qualitative difference between tripping and not-tripping. (With a blurry line but you can easily stay on one side of a blurry line.)

Reply on news.ycombinator.com