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Comment by rasengan | Hacker News Reader

This is very legit. The results are tremendous. I recommend it to anyone, but with a doctor's recommendation of course.

Here is a study on adult humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/

Edit: Comment edited.

For another sample of one, I took Elysium Basis for several months, stopped, and then took a similar dosage of NAD and pterostilibene from other manufacturers. I can't say I noticed any obvious benefit from either regimen. Looking over article, NMN looks like the more interesting compound, and it does seem like some human trials of it are in progress, e.g.[1]

1: https://clinicaltrials.gov/ct2/show/NCT03151239

> I can't say I noticed any obvious benefit from either regimen

What could you have noticed?

Not sure if you meant that as "it's obvious nonsense so of course you wouldn't have noticed anything" or if it was broader question about placebo/nocebo effect? I was just responding to the claim that taking NAD supplements could have tremendous effects - presumably I would have noticed those.

I've been taking Elysium Basis for a little over a year. I've noticed no effects, secondary or otherwise. I looked really hard at their research about (likely) effectiveness, and it did seem to check out.

But it is around $50/month so I'm not sure if I will continue to take it forever. Elysium is mostly a marketing company, so hopefully they will have competition and the price will drop if more research proves NAD's effectiveness when taken by humans long-term.

> the results are tremendous

What results are you seeing?

I was struggling to build muscle. My weight was really low. After adding Niagen (and a few other supplements) to my diet, I gained 10 pounds.

This was literally after ~1-2 years of 0 growth, and not much has changed aside from that in terms of my diet and exercise routine.

Why would an increased rate of DNA repair lead to increased muscular hypertrophy?

According to a recent study, it appears that "lower NAD+ levels are deleterious for muscle health and higher NAD+ levels augment muscle health. [1]"

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840929/

I only skimmed your paper, but it looks like any positive effect is from better mitochondrial function. While I’m sure that’s a good thing, it’s not what the article is talking about, so to say that your experience proves that it really works is a little misleading.

One person's experience never proves anything in a macro sense, as I'm sure the person you're responding to understands.

All it proves is that through actual biological processes or through placebo effect it has an effect on OP.

If you stopped the dosage, would you expect to lose the weight and muscle? Seems easy to test.

Can you share your diet and exercise routine please? I do have the same problem.

The study talks about giving the mice NMN, not Niagen. Are the two related?

Both NMN and NR (from Niagen) leads to NAD+!

I've seen it mentioned on forums. But what does science say about it?

- It WORKS in adults and is well received. [1]

- Having low NAD+ leads to all sorts of terrible, horrible, no good, very bad issues. [2]

- You need NAD+ for muscle and energy. [3]

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/

[2] https://www.ncbi.nlm.nih.gov/pubmed/29295624

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840929/

[1] does not say that it works, don't misrepresent the study. It found that certain markers were increased/changed by the supplement and that a few of the observed physiological functions appear to have improved a merit further study. Also, N=24 so ymmv. Seems like something that may be useful after further study but your conclusion is misleading.

Why do you find it necessary to have a creative commons license for your hn profile?

> Having low NAD+ leads to all sorts of terrible

Maybe "the low NAD+ levels" are a symptom, not a cause, since its linked to unrelated diseases?

I don't understand the conclusion; perhaps the NAD+ is the thing connecting the diseases?

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