I don't disagree with the point you're trying to make, but I'm not sure if USB is the best example to make that point.

Case in point: when I used a USB DAC with my NUC there's an intermittent electrical noise that's actually quite audible and distracting (even when nothing is playing). I ended up switching to another cheap DAC that accepts optical input, and the noise completely disappeared. I'm not entirely sure what caused the electrical noise to begin with, but that it existed means there's some potential for USB to mess with the audio signal.