I think the fundamental problem is that chrome just wasn't built to host a single application that never refreshes. It's optimized for opening dozens of websites and cleaning up resources in between page loads. This requires a certain amount of memory no matter what you do.
In terms of rendering performance there aren't any significant problems if the DOM manipulation is done correctly. It shouldn't be any slower than say Qt assuming properly written JavaScript.
I'm sure a solution can be found to solve those problems. However the sad truth is that no one who chooses electron cares about any of that and would rather point out how cheap RAM is and that you could solve this problem by spending 60€ on another 8GB of RAM.