The HUGE difference is that one is asking to use resources in a smarter way (safe injection sites). They are not destigmatizing drugs.
I've been to countries where there are 'tolerance' zones. But that doesn't mean there isn't stigma to doing it.
Stigma is a strong social disincentive.
The Healthy as fat is trying to remove stigma for something that is unhealthy. But it is not trying to re-assign social resources in a logical way.