The difference here is the accleration of climate change, estimated to be 10-50x faster than previous transitions from cooler periods[1]. One study finds that this accelerated warming could lead the extiction of 1 in 6 species[2].
[1] https://www.theguardian.com/environment/climate-consensus-97... [2] http://science.sciencemag.org/content/348/6234/571