1) The 5% return that produced the $45T figure is significantly higher than the expected return on capital for the vast majority of that period(which includes risk and is not comparable to modern returns). Furthermore, there would be no place to put that money to try to extract that return. The notion that the 18th century even had a safe positive return on capital for large periods of time for proto-investors is dubious to say the least.
2) The timeline doesn't fit for claiming that colonial India dramatically benefited the imperial center or periphery. The UK was industrializing and ahead of the rest of Europe before revenues from India are supposed to have made a difference yet fell behind countries like Germany(which lacked any colonies until the late 19th century) even as revenues from India were supposedly diverted. The periphery is no better, Canada and Australia fell behind the US even with the supposed surplus from India.
3) I'm skeptical that diverted taxes from a mostly agricultural society like India could have produced the bonanza suggested in this article. Existing Per capita taxes would have been onerous enough and not much more could have been meaningfully extracted from the peasantry. A pre-modern society has enough problems with basic economic management and political stability; sustaining a massive bureaucracy necessary to collect taxes without rents diverted to local elites doesn't make a lot of sense.
4) As an addendum to (3) the early East India Company lacked the ability to even administer the country without the cooperation of elites(which required the dispersal of rents). The later imperial bureaucracy necessary to administer India was by all accounts quite expensive. There just isn't the gigantic return form skimming off taxes that is suggested in the article.