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This one appeared on hn some time ago:

I use "Hack" in my editor, one of the only fonts that puts me at ease when programming. Other than that, I'm always happy to see the system font stack used on webpages.

there are fonts designed for dyslexia, they look weird but are actually fairly readable.

https://www.dyslexiefont.com/en/typeface/

https://www.opendyslexic.org/

i suppose the amount of science is open to debate but there are centuries of practice behind serif body fonts although the details depend a lot on the reproductive medium and other specifics.