A Prion Love Story (2013)
newyorker.com
newyorker.com
In particular, as the article notes, prion research is damned hard, and they had zero prior experience, and it's not the kind of thing you can put together yourself in your backyard with eBay supplies. But love and pure force of will pushed them forward and I don't think words could ever express how beautiful that is.
[0] Operation Epsilon, in a nutshell, was when we took a bunch of German nuclear scientists and put them in a bugged room and told them about Hiroshima and listened to their reaction, in order to figure out how close the Germans were to the bomb. I highly recommend reading the transcripts, they're fascinating.
Indeed, searching "autosomal dominant late-onset" does yield quite a few, in various species. Including autosomal dominant Alzheimer disease (ADAD).
http://www.prionalliance.org/2018/12/03/end-of-the-year-upda...