Gut bacteria may offer a treatment for autism
economist.com
economist.com
I am also intrigued about what this means for criminality and how the line between illness and evil is likely to shift given the role of microorganisms in behavioral dysfunction; and more broadly, we don't like to admit it, but it seems that completely amoral factors can be the cause of moral, amoral, or immoral behavior.
Believing in evil is its own kind of privilege. I for one have now seen a lot of criminal cases, and I've only seen sick people and people following the path laid before them. No evil in sight, but the concept's very existence allows for a certain social stability, to the detriment of some in favor of others.
The kind of people who believe they had no choice are the worst because it shows a total lack of remorse for their selfish decisions.
Phrases like “Look what YOU made me do” and “It’s societies fault” are warning signs that they learned nothing and you have a likely repeat offender on your hands.
You're missing the point: you don't always have a choice about which choices are given to you, and that has consequences too.
(To the GP of this reply, you might have misunderstood. I'm not really talking about you, personally, just using this short conversation as an example. Please don't take it personally.)
You're making the assumption of how your choice could have been anything different. That's an illusion and studying determinism is helpful in understanding why you're simply a biological input/output machine in a system being society. Even with the possibility of randomness existing as quantum mechanics suggests possible.. it wouldn't make a person have any choice. Personally I think quantum mechanics is just a result from a deterministic system that at this point in time is too complex for humans to analysis as determinism.
It's common knowledge that an outcome results from an action and maybe even consequences happen when the world is under the free will illusion. The problem is the actions were all based on the preceding outcomes and where nobody had any control.
> The kind of people who believe they had no choice are the worst because it shows a total lack of remorse for their selfish decisions
> Phrases like “Look what YOU made me do” and “It’s societies fault” are warning signs that they learned nothing and you have a likely repeat offender on your hands.
Ethics & morals help society strive for the best interest of humanity. The majority of society at any point in time, hasn't understood free will is an illusion and from my understanding of history. We're only capable of theorizing but from my experience, I have been able to remove resentment to persons who wronged me and because they had no control in how they became who they are with the actions they produced against me. I don't believe persons should be punished when they had no control. The best outcome is society learning how to prevent a similar unfavorable outcome and people rehabilitating the persons who were unfavorable by the universe to do a wrong.
I's a huge assumption to assume people will be repeat offenders under the belief of knowing free will is an illusion and when you're contrary to the ideology as you haven't been able to live under it for an extended period of time.
As for quantum mechanics allowing for the introduction of non-determinism; what part of the human body do people think they can influence? The brain is a neuron-neurotransmitter system, muscles expand and contract based on electrochemical signals, etc. Where in the mind-body connection is the mind/self capable of enacting this non-deterministic influence?
That being said, believing in a non-deterministic universe doesn't make life any less fun nor surprising. It does concretize my sympathy for people who are faced with unfortunate circumstances and carry out actions with unfortunate outcomes.
Are there times where I have thoughts that contradict that belief? Sure. I've accepted the highly contradiction-prone way the mind works. In the end it just makes the most sense to me.
Taking your thought process and building off the idea that everything is deterministic, we can frame the concept of “free will” as something that’s defined within that image of reality. In this case, why should you deny the concept of “free will” within a deterministic environment? Why not just define it as the random process that governs all of our ideologies? Additionally, why should you show sympathy to those in worse situations if everything is deterministic?
If society feels a need to punish criminals and remove them from society that’s another deterministic outcome that you yourself should know makes no difference either way in the grand scheme of things. Why someone would be deterministically wired to counter an argument by using their belief of a deterministic world on HN is beyond me though.
No, it's a huge assumption to create the "free will" theory with no evidence and then argue against the opposite position where I'm using what is observable in nature with science. It's like religious people that argue against people that don't believe in a god.
> but I can definitely say that you’re putting a lot of belief in it being true without any real evidence
No you can't, physics, neuroscience, computer science, and mathematics all favor determinism. If you chime out quantum mechanics, go search my comment history.
> Taking your thought process and building off the idea that everything is deterministic, we can frame the concept of “free will” as something that’s defined within that image of reality.
Yah if you acknowledge you're a puppet by external forces and love your strings. Your freedom is love for how your controlled because it fits you and how you have no real control yourself but are fine with it. Yet, I myself don't consider that definition of free will what most people think and to me it just doesn't exist because that definition would be nonsense.
> Additionally, why should you show sympathy to those in worse situations if everything is deterministic?
Humanity makes progress when removing illusions from society and being rational. Society shouldn't be punishing persons who were unfortunate by the universe. Society should fix the problem of what resulted in a person having an undesired outcome and then rehabilitating the person back into society. Same goes for social, health, and financial problems.
> If society feels a need to punish criminals and remove them from society that’s another deterministic outcome that you yourself should know makes no difference either way in the grand scheme of things.
Yah, whatever happens is destined to happen and similar to how society once viewed the world as flat and until some persons came along to get the idiotic majority to understand. Time brings progress or the opposite and it's all fated to happen. I hope you're not trying to make an argument against understanding reality by the mere premise of you would dislike how it really is.
> If society feels a need to punish criminals and remove them from society that’s another deterministic outcome that you yourself should know makes no difference either way in the grand scheme of things.
See above.
> Why someone would be deterministically wired to counter an argument by using their belief of a deterministic world on HN is beyond me though.
Short answer: Go study determinism.
So if you believe in group selection has a large role in how society is shaped and will evolve then perhaps society's best interest is only to rehabilitate the troubled person only if the expected cost is lower than the expected reward. If you don't believe in group selection is that crucial then maybe it would be apparent why people like to punish if you take a look at game theory and experimental results with public good games. Keep in mind you are also making the mistake of assuming society has some sort of telos, or that moralism realism is true. So in that sense, if you ask me China's government seems very sensible in several policy areas because it doesn't give a shit about individuals.
Anyway cost of society is something I don’t even believe is worth pursuing a discussion about with me anyway. I have witnessed from my own personal experiences with how medical treatments are handled completely irrational to fixing my issue. I’m not fully aware to understand why but I assume some unknown agenda. I’m doubtful in any case, the persons going into professions from the start want that to be so.
China is interesting and I wouldn’t be surprised to find out their leaders operate with the knowledge of free will being an illusion. However it doesn’t mean they’re doing it how everyone would and with the same knowledge. Some people will treat the misfortunate as praedamnation and not care to make that go away. Believing birth into royalty of some sort is all that matters and shouldn’t change. However the deterministic universe has been progressing in the opposite direction of that.
But besides that, how can you ever believe such a thing without appealing to authority or religion. There cant be any free will; You are fully determined to execute on the given path. But that does not remove any responsibility - your unfree will is still yours just as the concequences, no...
(I mean, your will is determined in part by your gut. Everything you ever ate could tip the balance in some way.)
> Human beings, who are almost unique in having the ability to learn from the experience of others, are also remarkable for their apparent disinclination to do so.
But I feel that biological parents that raised children, who later on become evil and take other people lives -- are responsible, some how.
I am mentally, far from being contempt, with all these psychopaths (who (most of them), also have seen at some point in their lives, have seen a professional phycologist, regularly) -- go and kill defenseless kids or church/synagogue goers.
These evil humans (if they can be called that) -- should not have existed, and if they existed -- their evilness must, somehow, have been detected earlier. And that's where the parents, and, perhaps, the meds-prescribing phycologists/physiatrists come in.
I realized, that in not too distant past -- the kings and czar's suppressed uprising by executed not just the active uprisers, but their whole families, including wives and kids. As a deterrent.
I am not talking about that, but, may be there a way that parents can be held accountable to the actions of their children (even if they are more adults by the time they commit heinous crimes).
May be that will also act as deterrent against pure evil that visits those humans.
Here is a very hypothetical scenario, I am struggling with:
A parent shows a pattern of drinking an driving under influence. As luck had it -- nothing bad happened. Then the child, does the same (when already having a valid driver license) -- and a horrible accident happens.
Is there some moral responsible that the parent carries? Is there criminal responsibility?
Just as in my initial comment, I do not know if this line of thinking has any merit at all.
Perhaps it is a 'bunch of baloney' as you put it.
I also have no idea on how to detect, that there in what instances there is an implied accountability of a parent (or a treating phycologist/psychiatrist).
I am hoping that some folks reading this thread , have historical, or even literature prospective that explores this angle.
How far the accountability of a parent or a treating phycologist goes/overlaps with the accountability of the perpetrator of a heinous act.
I can see that out of all the feedback on my comment so far -- there is 0 overlap of accountability suggested.
Thank you for your feedback.
> A parent shows a pattern of drinking an driving under influence. As luck had it -- nothing bad happened. Then the child, does the same (when already having a valid driver license) -- and a horrible accident happens.
Children definately imitate parents. But I think your argument was the opposite. Parents reporting on Children's behaviour if they fall out of line.
> How far the accountability of a parent or a treating phycologist goes/overlaps with the accountability of the perpetrator of a heinous act.
World is a messy and scary place but trying to control for every variable might make it unlivable.
I do not know how to detect this stuff, but I feel morally responsible , for behavior of my children, for example.
Why should I not be partially criminally liable for their misdeeds?
God forbid, a child drinks alcohol or smokes some chemical substance, then gets behind a wheel of a car -- and kills a family going to a picnic.
I am not even thinking of more serious premeditated horrible crimes.
As I said in the beginning of my post, I do not know how to express this correctly -- but I feel that there is more role (and accountability) that parents and doctors treating mental illness/behaviors -- should bear.
But I would like to put forth the argument that people get closer to gaining the required awareness that would make them free as time passes and they gain experience. This is similar to limits in math.
That is not to say that everyone moves in that direction at the same speed - that part is indeed out of one's hands. But it is undeniable that experience increases, and with it, awareness and thus freedom.
I don't think I believe this because of ego. I just think it happens to be true.
Just to clarify my view: I think there is a threshold of experience beyond which one becomes "formed" (as in, the word formative). Beyond that point, I think free will, and consequently, personhood is real and we're not just automatons. This is not a new argument; I just wanted to clarify my view.
Now even if we could perfectly, objectively rank it, should we immediately jail the bottom 1/3/10%, or should we wait for them to commit a crime? Should we give lighter sentences to more empathetic people who commit crimes, assuming they had better reasons to do it?
This kind of discussion leads down a path where we try to quantify something that's incredibly hard to quantify in a vacuum.
The question of willpower is also only relevant when you try to find an appropriate punishment for immoral offenses. And because this is hard, every country on earth has courts and trials - which can take forever for good reason. Because it's already hard on a per-case basis, let's not try to find an answer that would be applicable to every offence ever.
Once you're through with your offender you should give them a probable path to redemption and back into society regardless of whether they lack willpower or not - especially if they lack willpower. Punishing someone for their lack of willpower and then closing every door in their face is a sure way to make them a criminal for life. And it's also petty.
Tell that to holocaust survivors.
If you want to redefine commonly used words like "evil" until they no longer have any sort of meaning, go ahead, but in that case you might as well accept a nihilistic existence as an automaton obeying the deterministic time evolution laws of physics. I feel like the rest of society will ignore you in that case, and that's probably for the best.
> I probably already engage in acts that future generations will consider evil
It's nothing to do with new insights coming about. If for example you reap the benefits of wars of aggressions and don't speak out against wars of aggression, what future generations think of it doesn't matter.
When you see a homeless person sleeping in the cold, and you put a warm blanket over them and they don't wake up and nobody sees it, was it a good deed? I would say yes. It will even remain a good deed if you yourself forget about it.
So why would that be different for bad deeds? It can only be bad for reasons that are present at the time. If someone is getting deceived it's hard to blame them. But if someone is ignorant because they made many little choices to remain ignorant, it's different. If someone couldn't have possibly known because of scientific discoveries made later, it'd be silly to "blame" them. But that's hardly relevant to the Holocaust.
And nobody "statistically" does x murders and y good deeds each year. We do nothing statistically, we just do what we ourselves actually do.
> Of course, the terrible things I heard from the Nuremberg Trials, about the six million Jews and the people from other races who were killed, were facts that shocked me deeply. But I wasn't able to see the connection with my own past. I was satisfied that I wasn't personally to blame and that I hadn't known about those things. I wasn't aware of the extent. But one day I went past the memorial plaque which had been put up for Sophie Scholl in Franz Josef Strasse, and I saw that she was born the same year as me, and she was executed the same year I started working for Hitler. And at that moment I actually sensed that it was no excuse to be young, and that it would have been possible to find things out.
-- Traudl Junge
While we might "pity" people in the past for not knowing many things, moral judgement has to do with the options someone has. Even if the majority is using their options badly, that doesn't mean those options didn't exist, just like there being less stars wouldn't make the rest of the night sky brighter.
> The sad truth is that most evil is done by people who never make up their minds to be good or evil.
-- Hannah Arendt
It's symbolic, but somewhat of an interest in this thread.
That line is already in trouble because of genetics research, psychology research, etc showing that people's actions are less based on deliberate choice than they'd like to believe.
Of course, this all causes issues for society since (for good or bad), a stable society kinda needs to at least pretend humanity have some general sense of free will otherwise a lot of things (like the aforementioned justice system) stop making sense.
They are very relevant, because then the question becomes "how do we best protect everyone, including the offender". It's highly unlikely that imprisonment is an appropriate medical treatment or harm minimization procedure for a medical condition.
I'd like to know more about this. Do you have sources for these?
It explores some case of brain malfunction leading to various criminal cases and what it means for free will (or lack of). Really makes you wonder what freedom do we really have.
[0] https://www.theatlantic.com/magazine/archive/2011/07/the-bra...
S. Boulardii is fairly widely known as having a pretty broad range of positive effects, so trying it out was a no-brainer. I have tried many, many things over the years and have improved greatly.
On a related note, it is common to assume that confirmation bias or the placebo effect would distort my judgment, but it turns out I am objective to a fault, as any objectively measurable intervention that I thought worked was later tested experimentally and confirmed my results.
There is actually nothing wrong with taking a guerrilla approach to health if doctors can't help you, as long as you don't fall for the "alternative for alternative's sake" fallacy, and are willing to bear the costs of iterating through the most promising interventions and not being disappointed when most of them fail.
Few questions:
- what positive effects did you get taking S. Boulardii ?
- did you try reuteri ? If no why ? If yes what happened ?
- what forms did you take the supplement in ? What form do you prefer and why ? Any brand recommanded or things to watch out ? Do you know natural reliable food sources ?
- can you tell me more about your 3 courses of H. Pylori eradictation ? Why ? How ? What are the results and costs ?
- did you notice what in your life may cause you to loose a proper gut content ?
And if you ever have the time, can you give a long explaination text about your overall experience ? That's the kind of information I'm mining hard for. I do understand it takes time and also that you are not a doctor and cannot be considered a representative sample. But it's very interesting and hard to find information.
- what positive effects did you get taking S. Boulardii ?
Intestinal "well-being," feeling I can almost forget about my intestines, whereas normally my abdomen always hurts very badly, to the point my entire body is straining in reaction to it. This is only in combination with the other measures I took; S. Boulardii alone is insufficient.
Whenever my intestines felt fine, my head felt clear and my nose/sinuses would stop being congested; and vice versa. This phenomenon has been consistent throughout my illness and has led many a doctor to scratch his/her head and/or not take me seriously.
I tried doubling the dose after reading about that on the net (some people take 25m+ CFUs), but it gave me dryness/constipation and resulted in diverticulitis so I gave that up.
- did you try reuteri ? If no why ? If yes what happened ?
Only as part of larger probiotic formulations. I don't tolerate most and I'm not sure why. It may be that some strains produce histamines or include FOS (when I iterated through probiotic products, I was not aware of FOS - please see my other reply below where I discuss FOS). So I don't have any experience with it.
- what forms did you take the supplement in ? What form do you prefer and why ? Any brand recommanded or things to watch out ? Do you know natural reliable food sources ?
I take KAL S. Boulardii (ordered from iherb). I use veg. capsules because of a bias I have: I had bad side effects to a few liquid probiotic formulations I tried early on, so I ended up avoiding them as a general rule (which might be invalid but I have no further need to re-test it).
- can you tell me more about your 3 courses of H. Pylori eradictation ? Why ? How ? What are the results and costs ?
The reason I got the treatment in the first place was chronic inflammation in the stomach and intestines. I also had severe chronic sinus inflammation (enlarged turbinates specifically) that never abated, and a very bad response to histamines (redness, itching). I had asthma-like throat constriction; a doctor once told me "of course your heart rate's up, you're almost choking!" after I went in because I felt out of breath. I had a general drunken feeling, and would even get giddy at times. I have considered the possibility of auto-brewery syndrome, but there's no way to tell now. The doctor was a gastroenterologist so he focused on the digestive issues.
After the eradication therapy, that all got much worse and I developed noticeable food intolerances. I think I was already sensitive to those foods, but not enough that I'd notice at the time. I specifically could no longer tolerate dairy and sugar at all, and I had to greatly limit harsh foods (acidic stuff like vinegar, or very salty foods) or else I'd get gastritis extremely quickly (confirmed on endoscopy). My scalp started to itch and lots of hair fell out in my crown area. I am better with dairy nowadays but still can't have sugar, and vinegar just destroys me (I guess because it is corrosive AND high in histamines). I also can barely eat acidic foods and have to avoid most of them.
- did you notice what in your life may cause you to loose a proper gut content ?
I had always felt great until the age of 11, then it hit me and I started to have "attacks" which I didn't understand at the time, and doctors couldn't figure them out at all. I was given a bunch of things like nasal steroids for the sinus issues, and some symptomatic treatment for the stomach.
I felt so terrible though, literally like I was dying. I imagine waterboarding feels like that, because I just felt like I was unable to breathe adequately and even though it wasn't visible, I felt like I was making a contorted face all the time because of the feeling of straining. I kept asking for help but after doctors couldn't find anything, my parents began punishing me for what they thought was malingering (long story there - but they are forgiven and we are on good terms now).
I have some theories about what caused it but nothing concrete. I moved country (continent too, in fact) just 2 years prior and hygiene was far worse. I went through several bouts of gastroenteritis. I also got a salmonella immunization (capsule) and the doctor instructed my mom to open it up and release the powder in some milk, to make it easier for a child of my age to swallow it. I got extremely sick with some kind flu-like illness + gastroenteritis after that, even though my siblings who took the same immunization did not get sick.
Please see the reply I made below for some more details if you're interested
edit: I forgot to mention something relevant that would relate my experience with the article. A while back I read an article written by an autistic man, in which he mentioned "face tightness" being part of his being autistic (I only made the connection later so I don't know how to find it again). I truly think there is something to that. I felt strained and neurotic whenever my symptoms flared up, and I was quite antisocial in high school, yet mellow on the few days my symptoms cleared up.
edit: further details added. I typed this up a bit quickly (it's late here) so I had omitted some important things.
This is interesting, considering that acidic and salty environments are the ones which naturally harbor beneficial bacteria and yeasts. Quite the paradox you have!
Also, vinegar is fermented and thus very high in histamines, on top of being corrosive.
Like yours, it’s a long story.
I've only ever made 2 top-level comments related to this issue on HN and they have surprised me with the amount of attention they generated.
A lot of people are going through desperate times because of conditions like this. It's hard to appreciate how bad it can be just by trying to imagine the symptoms for an instant. It's much harder to imagine what it feels like to experience that for months; years; decades.
Self described sensitivity to gluten is on the rise. Possibly some gluten intolerance is on the rise, too. However, incidence of -actual- celiac disease as confirmed by biopsy has not changed, but screening and diagnosis have gotten a lot better.
This is a bit more readable: https://www.the-scientist.com/features/the-celiac-surge-3143...
In a nutshell: the expression of a gene within an individual can change over their lives, and the changes can be inherited. There are multiple mechanisms of alteration and inheritance.
The field is still in very early stages of research, but here are some paraphrases from Wikipedia to hook you:
* Children born during the Dutch famine of 1944–45 were smaller than those born the year before the famine and the effects could last for two generations. They also were at increased risk of glucose intolerance in adulthood.
* Children of women who were abused during pregnancy were significantly more likely than others to have methylated glucocorticoid-receptor genes, which in turn change the response to stress, leading to a higher susceptibility to anxiety
* Male mice that participated in voluntary physical exercise resulted in offspring that had reduced fear memory and anxiety-like behavior in response to stress.
For further reading:
* https://en.wikipedia.org/wiki/Epigenetics
* https://en.wikipedia.org/wiki/Transgenerational_epigenetic_i...
* https://en.wikipedia.org/wiki/Epigenetics_of_anxiety_and_str...
--- Pure conjecture ---
As an engineer, this sounds like coarse short-term evolution; a dimmer switch for various genetic functions which can improve offspring fitness relative to a sudden environmental change, possibly with negative side effects, until the environment stabilizes or genetics can adapt with new functionality.
Only now, our population is mixing over broad geographic areas subject to an unprecedented acceleration of environmental changes, with often no prior genetic training, as cultures shift towards sedentary, inside, less-social lifestyles that have fewer children at greater ages.
An inter-generational epigenetic analysis of celiac, autoimmune, and other "new" diseases could be ground breaking. I'm wondering to what degree they are emergent symptoms of possibly conflicting epigenetic adaptations accumulated over multiple generations. The timing is just so suspicious.
The mouse study of stress tolerance also suggests follow-up studies that may have fascinating political ramifications.
What works for my "aging" problems (age 40)? Carnivore diet helps to some degree (with weight, testosterone, energy etc). LLLT on the head works really well for me to boost mental acuity, or any form of stimulating light (10k lux lightlamp). It's has been life changing for the past 1.5 years (LLLT device costs $30). https://www.selfhacked.com/blog/my-review-of-lllt/
Best of luck!
2) CMVision UL Listed Regulated Power Adapter, 12VDC, 2Amp for Camera, LED Light, IR Illuminator
both from Amazon. 850nm, 96 LED, 2amp 12V adapter.
Don't forget to close the light sensor in the lower left corner when you apply I apply it for 60 sec on upper-front head area every other day. The effects are pretty noticeable for me.
One article that comes to hand: http://well.blogs.nytimes.com/2014/10/06/when-gluten-sensiti...
Regarding diet, I started observing the effects of everything I ate and adjusting accordingly, somewhat like an elimination diet. I was actually really clueless at first and had numerous deficiencies as a tradeoff for some of the symptoms disappearing (which was great but not sustainable). Over the span of years, this has improved and today I have no deficiencies and only relatively mild symptoms remain.
The biggest breakthrough was limiting fermentation, by taking the FODMAP IBS diet to its natural conclusion, and eliminating everything that would ferment (and thus increase intestinal microorganisms, which for me were imbalanced). What prompted me to do this was trying 2 similar probiotic formulations, only one of which had FOS. The one with FOS caused a huge flare up. So I greatly reduced fermentable things ("resistant starches," "soluble fiber," "FOS," "FODMAPs", fructans, sugar alcohols...). Caprylic acid supplementation really reduced fermentation whenever I made a dietary mistake.
I googled that idea and found the blog of Dr. Norm Robillard which advocates for a similar low-fermentation diet. Interestingly, the people who commented on his site seemed to divide into 2 camps: low-fermentation people vs. those who did well on the opposite diet (high starch / fermented foods).
Adding S. Boulardii then reduced my symptoms further (brain fog, chronic intestinal inflammation) and I feel pretty decent now.
I cannot yet figure out how to make it so my intestinal microflora is balanced enough that eating fermented and/or fermentable foods wouldn't destroy me. I'm still working on that in my spare time.
Do you have research notes, on methodology and things tried? I'm now very curious for myself.
edit:
I've also not written anything about methodology, so I hope my writings have not given the impression that one can play fast and loose with supplements. I actually follow a safety-first approach, and I do this only after a doctor reaches a dead-end.
General approach for evaluating supplements:
1- Find out about something that sounds promising, either by accident, or googling ideas and stumbling upon something that claims to improve your condition in some way.
2- Skim reputable sites (that cite research) listing the potential pros and cons of the supplement in question. Stop here if there is an unacceptable level of risk.
3- Skim any research about the supplement vs. your condition.
4- Read Amazon/iherb/other customer reviews for formulations of the supplement. Do not get excited. Most of these reviews are fake. What you are doing here is scoping out the ideal claimed outcome as a screening tool. If the ideal outcome is not worthwhile, stop here.
5- Dig into the research yourself. Confirm the level of risk. Check interactions. Determine whether there is a chance of the supplement working.
6- Purchase and test product. Remain objective. The baseline expectation is that nothing will work. Don't be emotional about that. I love having experience with products regardless of whether they work for me or not. I find it very interesting either way.
Here's a temporary email address: something@radiodale.com
Please email that address and I will give you my real email address there. This is to avoid publishing my email for perpetuity.
Very true. I added your disclaimer.
Killing of species of your gut microbiome (by eliminating foods) should probably not be somethig to take lightly.
I have been taking the peppermint oil tablets from helpforibs.com and they are good for temporary comfort here and there but my gastroenterologist has not recommended the things mentioned here. He has written off probiotics as useless and also downplays dietary adjustments for some reason. It’s really wild. I have found fiber and grains are great for me and eating rice every day is an enormous help.
I'm suffering from somehing similar. Did you look into Candida? A lot of the symptoms sound very similar. H. Pylori antibiotics could have killed off good intestinal flora, causing candida overgrowth.
Could you describe what other changes did you make, aside from adding S. Boulardii? Diet, supplements, medications? What helped you the most?
You are right to assume that the problem is fungal, since it started after antibiotic therapy, but I find that fermentation of any kind makes me sick - even supposedly anti-candida things made me worse if they were fermented (claimed to provide tons of antifungal probiotics). I have had much better results admitting that I do not know the actual imbalance, and thinking of this as a known unknown.
The supplements that helped me most were caprylic acid (for reducing gut dysbiosis) and S. Boulardii, even though you cannot take both at the same time (the former weakens the latter).
I also benefited greatly from taking nutritional supplements to top off any deficiencies of vitamins and minerals I might have had, but I do not take these things continuously, because supplements usually have specific forms of ingredients that may compete with others - for example, you'll often find Vitamin E as alpha-tocopherol, which is OK for topping off your levels but in the long run, it depletes other forms of Vitamin E such as tocotrienols and other tocopherols.
See my other comments for more details, I wrote quite a bit.
What about instead of sampling randomly selecting individuals to try a treatment?
I'm often overwhelmed by the amount of information about options out there.
My approach is to rely very heavily on heuristics in order to screen potential treatments. I wrote some steps describing how to do that elsewhere in this thread.
Your heuristics seem useful. I've been just trying stuff for a month and seeing how they go. Trusting the professionals to guide me in semi-useful directions.
Thanks.
Certainly research on mouse models of autism is a big deal: I see summaries of new such studies multiple times a week.
variants of the virus that caused their hosts to socialize more replicated more
I've often postulated that the necessity of a Subject in English sentences causes us to inadvertently project agency in our descriptions of events / phenomena that in reality don't have an "actor" in a meaningful sense.
It's fascinating to consider to what extent this false notion of causation and agency may constrain a native English speaker's understanding of the world.
As a native English speaker, I disagree; it is a perfectly natural way for the intended message to be communicated in English.
> I've often postulated that the necessity of a Subject in English sentences causes us to inadvertently project agency in our descriptions of events / phenomena that in reality don't have an "actor" in a meaningful sense.
A subject need not be an (semantic, much less also self-willed) agent (and, when it is, it can , and misleading anthropomorphization is in no way a peculiarity of English speakers.
“Evolution favored variants which enhance host sociability” has a subject, which is a semantic (but not self-willed) agent.
“Variants which enhanced host sociability are favored by evolution” has a subject, which is the patient rather than the agent.
Both are quite natural English expressions, and (unlike attributing will to the virus) accurate (or, at least, describe a plausible phenomenon.)
"host-sociability-enhancing variants replicated more"
By extension, most if not all molecules that are present in the plasma.
I'm inclined to think the link in autism might be caused by the prevalence of C-section births not passing the proper gut microbiome to some kids who are also genetically more inclined to autism but only if the gut is screwed up at birth.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464665/
Doctors nowadays do C-sections often for unnecessary reasons, such as expedience or shift changes or as a default because the believe its "safer":
https://opinionator.blogs.nytimes.com/2016/01/19/arsdarian-c...
The wrong micro-biome eventually builds up a toxic load that causes the onset of autistic symptoms. Most likely due to cell danger response (CDR) getting stuck:
https://health.ucsd.edu/news/releases/Pages/2017-05-26-centu...
Out on a limb, I know. But likely the cause is probably going to come down to a cascade of preventable events and toxic loads causing some kind of malfunction in those who are already gene compromised.
[0]: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020209/
[2] https://qz.com/1034016/the-class-dynamics-of-breastfeeding-i...
If there was a place where one could submit anecdotal experiences then you could analyze that data and use it as a basis for professionally run medical experiments. For example, if 1000 people said X food triggered symptoms of severe depression for a few hours after consumption then a professional could look at that and say "this is something worth looking into". You would be correct in remaining skeptical of individual claims which haven't been carefully verified, but you would be a fool to just ignore and discard those claims.
Mikhaila Peterson is one example of an individual that was suffering from serious chronic problems who found a solution that appears to work for her. She's now on a carnivore diet, which means she only consumes meat and water. Now, that doesn't mean that everyone should go out and start imitating her, but it sure as hell sounds like something that medical professionals should look into.
I'm more worried that people will latch on to the gut connection and experiment with other "cures". There's an entire world of people poisoning their kids to try and cure "gut problems".
Interestingly l Reuteri is also found in human breast milk.
When I looked into breastfeeding, different sources said it had oxytocin in it which made people feel more connected or increased trust. Made me start wondering if society's break from breastfeeding might be causing a lot of social and family problems since the bootstrapping phase of trust wasn't there anymore. That's on top of how childbirth happens in hospitals treating it like industrial process.
Now, you say that's in breast milk. Now I'm wondering if we can add the problems it might knock out to the list of negative effects of no breastfeeding.
Recently I started considering the possibility that being fat could actually a symptom in some people. Controlling your weight is really easy when you're fairly healthy, but when you're sick it can become much more challenging. I used to be fairly critical of fat people, thinking that it was laziness, but I think the numbers are just too large to chalk it up exclusively to any single thing. There's also a lot of fat people that work incredibly hard and they excel at tons of things, which brings the laziness hypothesis to question. It's entirely possible that laziness plays a role in some, but when you take a high-resolution view of the world it's rare to find single-variable answers to complex problems.
We also know that your mouth bacteria can have a huge impact on your dental health. There's people that barely have to brush their teeth to maintain perfect dental health, and others that still manage to get cavities despite following fairly rigorous routines such as brushing and flossing after every meal. I'll note it's been a few years since I last looked into this claim so take this comment with a grain of salt.
Trying out probiotics seems fairly safe and it could have hugely positive effects on your health. The sibling comments from theprotocol are just one example. To add an anecdote, I recently started taking probiotics and the first thing I noticed after a few days was that I no longer felt tired after eating. I've experienced a few other positive changes, but I haven't been taking them for long enough to feel confident that those changes can be attributed exclusively to the probiotics. My biggest issue with probiotics is that finding good information about different products is fairly difficult. I basically just picked a box at random out of all the choices available.
Does anyone have suggestions of good book on this topic? I've seen The Mind-Guy Connection and The Good Gut floated around a bit, but they have mixed reviews and the scientific rigor behind some of their claims seems to be under question.
That said, this research actually genuinely attempts to research causation, where most of the other studies I've seen linking gut microbes and autism are essentially only demonstrating correlation. Anyone who has spent any time trying to make a picky autistic child eat a varied diet will not be surprised by this correlation.
The post it replies to says it "may offer a treatment for autism in mice." The not-at-all vapid statement is that one should be cautious in that even if it works in mice, there are many examples where this did not transfer to working for humans.
What is autism in mice in the first place?
What kind of fucking degenerates are "studying" or "modeling" a cross-species "mental" disorder???
On species with an almost unrelated brain structure as a "model"?? What kind of bullshit is this?
Feel free to experiment on humans first before trying mice.
> What is autism in mice in the first place?
Social behavior, measurable effects you would also use for diagnostics in humans etc.
> What kind of fucking degenerates are "studying" or "modeling" a cross-species "mental" disorder???
People who are smarter than you, obviously.
https://plus.google.com/photos/112611364634545455505/albums/...
I am one of the few parents that could recover the kid from Autism. We have been crying wolf that it's a gut related issue, but mainstream is now slowly catching up.
Now I have to actively avoid Americans that don't understand this. Some have such strong feelings, adverse to trying new things. I've been on the receiving end of lectures many times about how my food is rabbit food. Or it "Doesn't have enough protine."
The types of bacteria that thrive in your gut varies depending on what you eat.
High fiber is more likely to result in a healthy balance of gut bacteria. However, if you already suffer from a damaged gut, a high fiber diet can be difficult, so be sure to increase fiber slowly, and with awareness of how it affects your body.
That being said, if you want probiotics, plain whole milk yogurt is the way to go. (If you can handle dairy.) I avoid the bifido type bacteria; though that is for very specific reasons. Acidopholus, l. casei, Lactobacillus bulgaricus and Streptococcus thermophilus are all fine, the latter two being the traditional yogurt bacteria.
I have mild IBS and had done some exploration prior to asking this question. In my personal experience, the above is definitely true. The wrong probiotic can worsen symptoms or make you feel sick/feverish. But I eventually found one that works for me, I take it daily and it definitely reduces symptoms and makes my gut feel more solid. (I even have data proving this; I ran two three-month data collection periods to test various interventions, quantified symptoms, ran regressions, etc)
They tested only multi-strain probiotics vs "aFMT" (fecal transplant). That is a far cry from saying "probiotics don't work".
In contrast, fecal transplants have been shown to be effective for some diseases.
Also, I can't even say mine are actually working for me, because my doctor also told me to start taking soluble fiber; that could be my magic bullet. It's a process, I'm still going to be experimenting depending on how the next few weeks go.
Example that some of parents are trying to tell the world that Autism is a gut related issue.
It’s not impossible, but it is very expensive. This is partly why medical tech takes about 10-15 years to go from invention to deployment.
Lactobacillus reuteri MM4-1A (ATCC-PTA-6475)
I am noticing how important gut health is to overall health as I get older. I feel like maybe children express poor gut health in different ways, for example by asthma, allergies, type II diabetes, acne, ADHD/hyperactivity, autism, etc. It's looking like autoimmune diseases are tied to inflammation in the gut, which is exacerbated by poor western diets saturated with sugar/soy/corn and herbicides/pesticides like glyphosate (Roundup) which disrupt intestinal flora. This is an inconvenient truth for factory farming though so will probably take 5-10 years to show up in the literature and become mainstream knowledge.
If anyone can cite research on if mice can develop autism or not I would love to see it.
Edit: there is a study published by Nature mouse models of autism with behavioral genetics. https://www.nature.com/articles/4002082
But the effects of that paper linger on among conspiracy theorists. Let's hope this one doesn't have similar consequences.
Meanwhile, as a guy "on the spectrum" I'm going to try a subjective bioassay of L. reuterii. Can't hurt.
There should be ample opportunities for diet to change even earlier on - incidents that seem like they should add up to documented evidence if there was something there. I mean even with a case with complications like scurvy - the vitamin C couldn't be measured and it was there in fresh food but not most preserved food and why citrus were the examples that could retain it. Of course there was also some astounding utter refusal to learn there.
Probably not; systematic empirical investigation isn't exactly their thing, so even if their intuition (or deflecfion, depending on how you look at it) was in the right neighborhood (diet and digestion if gut bacteria offer some real help), doesn't make it particularly likely that they’d stumble on to the right thing.
(Of course, this is just an opinion.)
Hard work enables us to leverage chance events (if we recognize them) into some probability of success, but the rest is outside of our control. Life is chaotic. We're all just pieces of a big entropy machine.
It's the butterfly effect at scale.
The chemical reactions driving cellular machinery is influenced by quantum randomness, while astronomical scales seem to be entirely deterministic (though chaotic). For example, radioactive decay influences both DNA replication and planetary orbits (via heat-driven plate tectonics)... but it seems that any randomness is washed out by the sheer volume of matter at the planetary scale.
We sit right in between those orders. Our bodies are an interconnected web of non-deterministic cells cooperating to maintain higher-level order and some approximation of determinism. Obviously I can't say with certainty, but I find free will to be more likely than not.
This is a contradiction. "Free will is the ability to choose between different possible courses of action unimpeded"
In this case it's based on a heuristic. I can't at all model human will so it seems reasonable to start with it as infinite (since it's so vast and appears virtually limitless, the very reason I can't model it in the first place) and model in the constraints.
edit: also, I am a Christian and that probably factors into my view subconsciously, although I am certain many non-Christian views would arrive to the same conclusion.
1) they are unsustainable (like harming allies) - not sure can be fixed
2) Don't have enough knowledge(broken perception) to do differently.
3) ROI of doing evil is too high.
etc.
Could you point to scenarios where aknowledging non-existence of free will could help us? IMO it doesn't matter.
EDIT: Actually I think that existence of concept of free will is positive because it makes people compute choices better (even assuming free will does't exists and computation is deterministic)
Short summary: I’m transgender and couldn’t transition when needed and to live a life of less pain because of others.
Arareness towards understanding people are who they are without any control brought me to realizing “who the best me would be” in the current situation. A person who cannot blame directly the person who wronged me. I might end my life by suicide though. So the impact of what others did to me was great and I still trumped it.
Perhaps we have alternative definitions of free will. I believe that whenever I (or anyone else) have made a decision, then rewinding time to the exact moment before the decision will only cause me to make the exact same decision again. I find the idea that I might decide otherwise disturbing.
One might argue that quantum randomness could influence decisions, but I would argue that adding true randomness to an otherwise deterministic system does not make it any more 'free', even if the system stops being deterministic.
I would love to hear how you define the'free' in 'free will', and how its existence follows from your argument.
1) People act according to past experience, environment and internal biology. 2) People environment also consist of the knowledge that "For any given situation there are many options and if one looks hard and tries one may choose an appropiate response". If the society emphasize on this aspect a person might be more willing to make a "choice". Of course not everyone will respond the same way to this knowledge.
1) doesn't imply that there is no "choice" and 2) doesn't imply that we are not "programmed" to behave in certain ways. Actually it might be that 2) is helping us to "program" people in certain way.
In the context of "crime and punishment", as we get better at 2) or someother scientific development we can reduce the need for "punishment".
The best analogy I could think of explaining the above language play on mind is following. Say you are training a new chess player to improve the game. You can say one of the two things: 1) For a given board position there are limited options. 2) For a given board position there are many options.
While both being true on thinking deeply they can have different effect on the person. It also matters what we emphasize. For a person thinking less 2) may be better thing to emphasize. For a person thinking lot 1) may be better to emphasize.
Punishment is the cruelest and most dehumanizing thing in this world by mankind. I view "original sin" being born into humankind "assuming free will" is correct. The barbaric justification for punishment is we will construct a deterrent for other humans. Yet, it's ignoring how we are punishing a person who had no control by "the universe not favoring the person" and resulting in others "being favored by the universe" from punishing the person resulting in deterrent to others. The whole thing is madness because it's the system that is flawed not the individual.
Assuming people can admit and learn from their mistakes means you can focus on rehabilitation and treat them with dignity.
If you have a system that produces defects, you could continuously scrap them, but you could also just fix the system so it doesn't produce defects.
Big if true!
I agree that the idea of "free will" might have been exaggerated too much especially in the US tradition, and I think people here generally agree. But taking a position of complete denial is likely not sound either. No need replying to everybody trying to defend your point. That in itself is a bit weak.
Basically the gist of it is whatever is destined will occur. However long until the social norms adjust for people to understand & see the illusion of today. How the belief is a substantial impact in how society functions but doesn’t even have any backing such as from science/reason. It’s similar to how the times are shifting of belief towards a god existing and how life must be played out from text associated with the belief. I even compare it to when humans all believed the world is flat. The possibility exists of the time to never come where the majority realizes free will is an illusion but I think contrary because I can understand from my experiences the positives. I can also imagine benefits from the realization of the majority understanding it and how the majority would need to function to still keep humanity as the highest regard.
You cannot take the stance that an illusion is how people in society needs to live under and seem rational to me. Similar to the stance of writing it as “in complete denial” and assuming likelihood. The topics on hacker news that have something to do with free will belief are my favorite because
I enjoy replying to everyone. It was destined for me and with others that reply. The main difference between me & others is probably how I have positive emotions towards the understanding because it made me able to not break in a very low time.
First, the argument is that if people do not have free will, they have no moral worth, yet society has moral worth. But no reason is given why society, composed of individuals rendered worthless, isn't also rendered worthless.
Secondarily, learning doesn't require free will, as empirally demonstrated by our pitiful machines today.
You have to state your axioms up front, and frankly the "news" of no free will is the greatest carte blanche to redesign morality anyways.
How it is possible to "study" anything about human genetic disorders in a such unrelated model as mice, which does not have any cortex and other major areas, including language related one?
Why treatment of the symptoms of unrelated disorder (any poisoning or radical gut disturbance surely affects behavioral patterns) is considered to be related to autism in humans, which has different causes, and manifests itself on a different brain structure and is unrelated to any gut bacteria whatsoever?
Why this crap is considered to be a respectable science?
> which has different causes, and manifests itself on a different brain structure and is unrelated to any gut bacteria whatsoever
How do you know it has different causes, when the causes of autism have not been enumerated?
> Why this crap is considered to be a respectable science?
I'm glad you don't get to decide. Maybe this will turn out not to have any impact in humans, but why not let the research play out - that's science.
In the current age religions has been obsoleted, but weak-minded "creative" people are still here. So, science became a new religion, especially when it hit the wall of empiricism, a limitation, which has been realized by ancient eastern philosophers (Brahman is unattainable to conditioned intellect which could see nothing, but its conditioning). Modern day's notion of impossibility to break an abstraction barrier (see the wiring of a processor from the level of code) is the very same notion reformulated.
Every bizarre bullshit could be framed as a hypothesis and published, giving a high social status of "theoretical researches" to its authors (instead of much more appropriate status of talkative idiots). It is due to social status, similar to those of a monk in medieval ages, which one's parents could buy for their children by paying them through a costly elite religious school. Nothing new under the moon.
I personally prefer to see those disconnected from reality academics, who gave advice to Macron (based on disconnected from reality abstract notions) to tax the population to combat climate change, to be held accountable for all the damages caused by resulting riots and being forced to pay for their ignorant arrogance, but this will never happen, because academics are allowed to produce bullshit labeled as working hypothesis. The rest of us aren't.
I come from a poor family, with amazing parents, but with limited resources. And sorry to say it in a time where autism "is a disease that needs to be eradicated", but I have my whole current living standard to thank of being a autistic.