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Comment by subcosmos | Hacker News Reader

Viruses that cause hepatitis actually embed themselves WITHIN LDL Particles (the "bad" cholesterol) to transport around the body. In doing so, they hide from the immune system.

APOE it turns out, the Alzheimer's gene, ALSO predicts your risk for liver cancer ...... because this is the gene that the virus binds to while assembling into the particle. Hepatitis virus infections are strongly associated with heart disease!

https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me...

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FYI, 23andme provides an Late-Onset Alzheimer's Disease report[1] based via the ε4 variant but does not test for a person's full APOE genotype.

[1] https://you.23andme.com/reports/ghr.alzheimers/

pssst .... APOE genotype predicts how much viral DNA for Herpes is found in the brain .... post mortem .....

It's almost as if Herpes viruses transport around the body the same way ;)

(Bar plots in this paper are LOG!)

https://jvi.asm.org/content/80/11/5383/figures-only

There's a theory that amyloid-beta plaques are protective reactions to encapsulate infections, which go out of control in Alzheimer's. As people age, the blood-brain barrier weakens, allowing more viral particles in. This is why people with herpes are at higher risk.

https://www.sciencedaily.com/releases/2018/07/180705143920.h...

I thought almost everyone had some type of herpes simplex (chicken pox, cold sores, warts, etc). Does that mean almost everyone is at higher risk?

Now I'm scared; 23andme reported that I'm at risk for Late-Onset Alzheimer's. What lifestyle changes can I make to reduce the risk of liver cancer?

Im a Phd, not an MD, but I'm currently trying to get my MD to see the light :

https://www.sciencedaily.com/releases/2018/07/180712100515.h...

Vigorous exercise may help with Alzheimer's.

https://www.health.harvard.edu/mind-and-mood/vigorous-exerci...

The results indicate that aerobic exercise is more effective than any currently approved medication in fore-stalling Alzheimer's disease.

Also , keep your weight down.

https://www.endocrineweb.com/news/obesity/55627-being-overwe...

A new study found a culprit for the increasing rates of liver cancer: obesity. The study published in the journal, Cancer Research, found that high body mass index (BMI) and a large waist circumference were associated with an increased risk for liver cancer. In addition, having type 2 diabetes, another result of obesity, also increases the risk.

Keeping weight down reduces risks across the spectrum, probably linked to the immune system. So nothing specific to Alzheimer.

take a daily herpes antiviral https://www.healthline.com/health-news/evidence-of-link-betw... and reduce your alzheimer's risk by 90%

Hey, I've been taking acyclovir for decades. Maybe I'll luck out. But at least, I avoid the excruciating sores.

Are you taking acyclovir solely for Alzheimer's prevention?

https://bottomlineinc.com/health/alzheimers/warning-a-cold-s...

A family member has herpes and recently started showing signs of dementia. I’m going to have them try that regimen. I’m also going to reach out to that doctor.

See also https://news.ycombinator.com/item?id=17540094 on the same stuff

Their FAQ actually provides all the pointers I was otherwise able to come up with, so is probably worth a shot:

https://you.23andme.com/reports/ghr.alzheimers/faq/

In addition, you may find it helpful to talk to a genetic counselor about your results; your GP/PCP should be able to get that sorted, although 23andme provides additional resources.

https://you.23andme.com/tools/genetic-counseling/

Intermittent fasting is showing promising results. Also probably the best bet for preventing diabetes and obesity.

The same is true for nearly every virus, systemic cancer, and organ disyfunction syndrome. Nothing astonishing about the ones you mentioned.

What if you have low LDL? Do good vascular health and healthy diet protect from the virus?

That's one hypothesis. Another one is simply that in some people, LDL is high because they have an infection that specifically turns on those LDL-making genes. It's known that many viruses hijack cholesterol pathways in cells.

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