And this problem being what exactly?
> It's very hard to say with any objectivity how much happiness, calmness, or attention is proper when your life situation may be bad, stressful, or boring.
And your solution is what exactly? Do nothing?
The reality is that it's not easy, but certainly not as hard as you make it to be. Most psychiatric diagnoses (including ADHD) have decent inter-rater reliability. They are certainly going to produce some amount of false positives and false negatives. But the moment humanity invent magic test for depression/anxiety/ADHD/etc, psychiatry is switching to it.
> So even if there is a biological condition that stems from brain differences, what is the R^2 between professional diagnoses of ADHD and actual biological cases of it?
Like I mentioned, brain scans are not really used for diagnosing (yet), because they are not sensitive enough to be used for diagnosis. How would you compute R^2 in this situation?