What do you mean by hard questions? Does it include things like "what happens after we die?"?
I think those questions are best answered by religion, but religion is being attacked, or at the very least, excluded in most thought-provoking venues.
Take for example the school that reject have Chick-fil-A on campus because of its (Chick-fil-A's) religious leanings[0]. Or the fact discussing religion on this very website is generally frowned upon - though that seems to be a reaction to people's recent animosity towards religion.
[0] https://abcnews.go.com/US/wireStory/school-blocks-chick-fil-...
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That said, I think religion can have a very real effect on opioid use/suicide, depending on the religion. See for example Utah, where the opiod rates, suicide rates and pornography rates are above average. I think that's a result of a complex interplay of factors. I think the gist of what's going on is that the "mormon" culture has squashed many visible vices - smoking, alcohol consumption and physical infidelity. Combine that with a streak of being judgmental / people trying to fit in (TGF, not in all places), and you get an over expression of harder to see negative effects: pornography consumption (though maybe Utahns just pay more for it... being more honest about it?), opioid use, and depression leading to suicide.
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With all that said, (disclaimer: I'm a member) I think the Church of Jesus Christ of Latter-Day Saints has plenty of missionaries who love to talk about (and answer) the hard questions (if I'm interpreting your post right). And I'm willing to talk about them too (my username as a gmail account). I'm not sure the answers will be satisfactory to you, but I've found them useful.