Big no-no in some parts of the world (yes, even the Western americanized world).
I remember an article on HN describing how the usual "So what do you do for a living ?" was very insensitive and an American woman had it hard striking a conversation with her husband's african dad (or something like that).
As a European I find this opener extremely aggressive, even in a friendly setting. It's the first line used by HR in a job interview. Not a pleasant way to start up a conversation.