The growing class divide, carefully curated media channels and a widening gap in haves vs have nots encourages an us vs them attitude. Combine that with a social media existence that allows you to select which highly tuned group you want to belong to and you've got yourself an information / viewpoint silo that breeds hate.
Then you have an ever-growing selection of consumer products that aims at creating a finely attuned solution to every need but in fact creates a sense of bewilderment and unhappiness.
Of course not all is terrible, as (some) businesses compete, you get better and better products / services (not always) that set a high bar for expectations. When the next burger, 4k TV or haircut is unsatisfactory, the feeling is compounded as we now have so much to compare to. How can anyone be pleasantly surprised when the bar to compare to is perfection?
Take our family again, the kids are going to college and accrue a ton of debt and are left to pay for it after graduation. No problems, unemployment rates are low, just go find a great paying tech job right? Well, now every entry job requires 2 years experience and nobody wants to hire college graduates. Take another dose of depression here and add it to your collective loneliness profile.
Then we have the corporate behemoths that stifle competition and create massive enterprises which control your life. Want to switch internet service? Forget it. No alternatives. Want to complain about a service you don't like? Good luck with that, you'll be connected to India and I'm sure they will put your suggestion in a corporate suggestion box... In some aspects we have too much choice and in others not enough. This of course leads to stress, frustration, anger, and despair - all of which feeds into the pool of depression. If yours isn't full, someone else's is getting there, and once it fills up it starts spilling out.
It doesn't stop there. US in particular is great at fostering a culture where we must blame everything on ourselves. Didn't get a good product? Your fault! You chose it. Didn't get the right president? Your fault! You voted for him. Didn't reach your personal goals after listening to that life coach / feel good guru podcast? Your fault! Don't you know, you're in charge of your own destiny! Forget asking for help, that's for the weak. Oh, but when you do, make sure to see a mental health professional since privacy is important (just don't complain when they share their information with insurance providers who will decide which therapy you should undergo).
Consumption, consumption, consumption. Take advantage of everyone to make an extra buck. Screw over your co-worker for that promotion. Outsource that job to an overseas contract worker - who cares about your fellow neighbor. Speaking of neighbors, why are they making so much noise? Well, don't bother talking to them because you know you won't. How dare you knock on their door and say hello, that's just weird! Nobody does that.
And people wonder why they are lonely...