I am ever surprised that they continue prescribing that one. Of the 10 I've been on that one was the harshest by far (though many others also had severe, dangerous side effects).
Background: I've lived my entire adult life (and most of my teens) with severe chronic depression. In my early 20's I started taking pharmaceutical treatment, and once I found the right drug (after trying many over the course of years) my life became manageable. SSRIs helped but I experienced severe nausea on most of them, or worse. It was only when I tried SNRIs like Effexor that things started to get better. YMMV, IANAPsychiatrist, etc, etc.
A few years ago I switched from Effexor to Cymbalta. Same class of drug - The Effexor simply wasn't helping as much as it used to and the switchover was done with a long taper-down and replace period. I even bought a lab-grade scale to measure out the contents of the capsules so I could cross-over smoothly.
All that said, Cymbalta has the same withdrawal effects, on about the same time scale - a single missed dose. But I wouldn't give it up unless something better comes along. I still struggle with my depression and the SNRI is just one tool in my toolbox for managing it.
I used to err on the side of double-dosing rather than miss a dose if I wasn’t sure, it is an absolute hell of a dependency.