Anecdotal FYI: missing one dose of mirtazapine feels exactly like a moderate hangover the next morning. I would vaguely hypothesize depression accrues in sleep, ethanol is indeed a CNS depressant with long-term effects and missing doses of medications causes much more harm than previously thought.

Also, I had some nasty vestibular dysfunction from withdrawing from vortioxetine... eyes randomly moving around quickly in all directions on their own, limbs twitching randomly, and any horizontal eye movement causing instantaneous nausea/vertigo.

And, I once titrated off mirtazapine and had some serious nausea... recommend ginger and weed.