As a ROOT guru and occasional pythonist, I recommend PyROOT especially if you want to interactively explore what you're plotting.
For example, ROOT has the concept of ownership, entirely distinct from the python sense of references. A file owns the histograms that were read from it. Closing the file changes all references to histograms read from that file to None. It took a large amount of digging to figure out how that was even possible (overwriting an existing object from within the C API), but I cannot for the life of me understand why.
ROOT has way too many gotchas for me to ever recommend it.