Prediction: lots of emerging startups who are basing their code on Python today are going to resort to this (or PyPy, but that's unrelated) when the scaling pain begins, or simply to attempt making things run a bit faster. I think this is great. Most people I know avoid C completely because of the hidden pitfalls every novice has to go through, but maybe Cython will slowly change that. It just needs a bit more maturity and some endorsements to pop up around here... which shouldn't take too long.