Well, yes and no. If your slice at 0.1mm with Hob3l, then slic3r can still decide that it uses 0.2mm or 0.3mm or 0.4mm slices -- it would just skip a few slices from Hob3l. I don't think there is a problem with that. It will get weird if you use Hob3l with 0.2mm slices and then slic3r with 0.35mm slices -- this will cause Moire effects. It is not wrong, but may look interesting...