They mentioned a few problems everyone knows about nuclear (NIMBY, financing, licensing, etc), but one of the unintuitive problems was the lack of institutional memory for construction. Westinghouse et.al. will design the core of the plant, but each plant is constructed by a series of contractors and subcontractors who many times, have never constructed anything this precise before. Jessica Lovering compared it to constructing cathedrals (in that each one was bespoke). This makes each one effectively as expensive as the last.
This is one of the many problems companies like TerraPower are trying to solve: Not just dropping up front cost (finance) or making it more stable (NIMBY), but also trying to build a living knowledge of how to build reactors repeatably.
Total tangent: My pet theory is that if it gets really bad, we'll just start building floating nuclear reactors and park them within transmission distance from cities. Ironically we have a ton of experience with floating nuclear reactors from maintaining a large nuclear-powered navy.
[1] https://www.greentechmedia.com/articles/read/can-we-make-nuc...