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And in fact the replication crisis in psychology suggests that the practice goes beyond just clinical trials.

The replication crisis in every field of science. Two-thirds of reported results cannot be reproduced.

If you haven't read it already, this article on the placebo effect a few days ago was interesting in how we on one hand use it as a baseline for measuring the effectiveness of drug treatments but actually can vary wildly between individuals. It's not surprising that results are so inconsistent.

https://news.ycombinator.com/item?id=18398342

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