I think the advantage right now is largely in a few select sectors right now, and mainly due to ecosystem.
Music production is a big one from my perspective -- currently, if you are looking at the tools and plugins that are the most popular in the professional world, your practical choice is basically between Macintosh or Windows.
The majority of DAW plugin synths / effects currently are not compiled for Linux, and I do not believe many popular DAWs (stuff like Ableton Live, Logic, Cubase, etc.) are currently supported yet either. I have heard that if you keep it light weight, some audio plugins will run just fine under something like WINE. But for a heavy-hitting plugin like, say, Spectrasonics Omnisphere, I have heard that emulation is too slow to be practical.
There are certainly native Linux DAWs and plugins out there, you can probably go quite far with Ardour or the Linux version of Reaper, and there's a few plugins too (u-He has some native Linux builds of their excellent synthesizer plugins for instance). It's just that the native ecosystem out there is quite a bit smaller, unfortunately.