To be fair, until we know in detail how brains work, we can't eliminate the possibility that esoteric physics are key to the their operation; we only rule that out with an adequate model that does not invoke such physics.
We know the physics of how some bits of brains work, but no model that goes from those bits to human cognition, so no basis beyond speculation and optimism for claiming that we know all the physics of how brains work.
"The Laws Underlying The Physics of Everyday Life Are Completely Understood"
Worth reading.
Give three examples.
Do not use the word "Obviously..."
Here's the direct link to the proof: https://www.am-nat.org/site/law-of-information-non-growth/
That doesn't necessarily mean we understand their behavior, of course. Complex behavior can arise out of simple underlying rules. That's hardly controversial, except (for some reason) when it's about human brains.
Until we can work out all the relevant implications of mundane physics and either find them adequate or not to model he phenomena of concern, we can't say that the physics of those phenomena are known (or say that they aren't; we’re in the realm of potential unknown unknowns.)
That the bits we know about are even everything that goes into cognition except how they hook up is somewhere between exuberant optimistic speculation and rank hubris.
Yeah, but we don't even have models to choose from. We can choose the model with the least new stuff when we have competing models; for now, we have models for bits and pieces of the brain/mind, but no wholistic model.
So, what we can really say about the brain or mind as a whole is that it's an open research question and we don't know what it will take to explain it.
We can absolutely say we have no particular reason to think esoteric physics are needed to explain the brain. What we can't say is that we have a firm basis for confidence that they aren't needed.
Brains can obviously provide answers to uncomputable problems.
I'm not sure how we'd be able to observe they they were “solving” even if they were to do so.
But, as for empirical evidence, max entropy + Bayesian hypothesis selection makes the PHO hypothesis much more plausible than the TM hypothesis.
It's not clear that all physically realizable things are Turing computable.