It takes a few weeks/months to develop your focus, attention span, and memory enough to be able to get near 100% short-term retention, but you start to see benefits almost immediately. And the long-term benefits to your memory and focus can't be understated.
Also, it's really interesting how many other people are expressing that they never took notes in college. I was famous for it in my college (my advisor wrote a paragraph about it in grad school recommendations), whereas I always thought it was common sense, seeing other people who spent the whole class scribbling, but didn't really understand a bit of what was actually taught.