You can absolutely use stand-alone "hi-fi" amplifiers for guitar; that's what I do. You just can't plug
your guitar straight into that; you need some pre-amplifier gear. My gear is old-school in a big rack, described below.
Nowadays, there exist units that provide complete signal processing for guitar: simulating guitar pre-amplifiers, amplifiers and speaker cabinets digitally. You plug your guitar into this, and then it can go straight into a PA system, or your recording console. Something like that can be used with an amplifier like the one being built here.
My rig consists of a 6U portable rack case with a few pieces of gear. The guitar goes into an ADA MP-1 MIDI-programmable tube pre-amp (built in 1987, revamped by me). This goes into a splitter-mixer (called the SMF-1 that I built myself) which bifurcates the signal through a digital effect unit that provides reverb, and then mixes it again. The dry signal remains analog. Then it goes into a 31 band equalizer, and from there to the power amplifier, an Alesis RA-100, which feeds a guitar "4x12" speaker cabinet (four 12" speakers). I could take out the amplifier and drop-in replace it with any rack-mountable amp, provided it doesn't require more than 3U spaces. QSC, Yamaha, Yorkville, whatever.
There also exist dedicated rack-mounted power amplifiers intended for guitar, like the Rocktron Velocity or Marshall Valvestate 8008 (both of these examples are stereo). Many of these kinds of ampls have been produced. These are just power amps; they can't produce any overdrive tones and have only minimal tone control or none at all. The 8008 has a switch on the back for "tube like" behavior, which just means current feedback. That will give it more of a mid-scooped frequency response, induced by the reactive speaker load. I can do something like that with my equalizer.
The amplifier project we see here could be turned into a guitar amp by adding a preamp circuit board into the chassis, fed by a guitar input jack, and exposing some tone and gain controls. The stereo function of the amp could be useful if we add jacks for an external effect loop and make it stereo (mono out, stereo in). Then we need a stereo guitar cabinet: minimally a 2x10 or 2x12 wired for stereo.