Why do you say that? Yes, $75M poses liquidity issues, but that doesn't mean that a smaller amount is easier. I'd wager that a smaller portfolio is harder because you can't diversify to mitigate your risk.
I can buy JDST at 9am for $60 and sell at 9:45am for $60.60. On a balance of $2000, this is an easy $20 for basically no risk, imo.