My experience has been fine once I got some good noise canceling headphones, before that I had serious issues concentrating. My main issue is not having long uninterrupted blocks of time to complete projects that require a lot of focus.
Lighting and other environmental factors are second biggest issue.
The simple fact that Panasonic sees a (profitable) need for something like their Human Blinkers, it feels more like a cure for the symptom and not the cause.
I'm not sure I get the fight or flight response, but I certainly am constantly aware of the people walking by constantly.