I was doing software security semi-professionally before the 8lgm Sendmail 8.6.12 vulnerability that set off the modern buffer overflow craze, and worked with a bunch of people frantically reconstructing that exploit (which wasn't published) --- the authors of the first x86 stack overflow vulnerability included my future business partner at Matasano, Dave Goldsmith.
It was light night and day! Before overflows, there was a whole variety of different "kinds" of exploits (you got some command injection with metacharacters, for instance with SunRPC services calling popen and system, but you also got "overwrite a file" or "leak a file" or things like that). Afterwards, it was just: every machine on the Internet had remote code execution via overflows.
It used to be feasible to calibrate an stack exploit for a remote service, for which you didn't even have source, in an hour or two of tinkering. It's crazy to think of how far things have gone since then.
Example ... about halfway through Issue 0x02 it is casually mentioned, "You will find by running ‘qemu-system-i386 -fda pocorgtfo02.pdf’ that the PDF file you are reading is also a bootable disk image." o_O !