Overdose deaths have fallen for six months
statnews.com
statnews.com
In that paper, the authors conclude:
> The overall mortality rate for unintentional drug poisonings in the United States grew exponentially from 1979 through 2016. This exponentially increasing mortality rate has tracked along a remarkably smooth trajectory (log linear R2 = 0.99) for at least 38 years. By contrast, the trajectories of mortality rates from individual drugs have not tracked along exponential trajectories.
The authors also suggest that we should attempt to "understand the forces that are holding multiple subepidemics together onto a smooth exponential trajectory", and suggest a double-whammy of increased supply (due to improved communication, transportation, and manufacture) and increase demand (despair, loss of purpose, and dissolution of communities) that cuts across both demographics and geographic regions.
--
But from what I recall, usuage rates of heroin in the population in the late 60s and early 70s was comparable to recent years, then fell a bit and remained more or less stable through the early 2000s. The return of addicted GIs from Vietnam prompted the start of the war on drugs by Nixon [1]
The big problem with heroin is what they are cutting it with. Prescription opioids, different ball of wax.
[1] https://www.presidency.ucsb.edu/documents/special-message-th...
this is especially dangerous amongst users who are relapsing and initially using their old dose amounts when starting again and their bodies aren’t able to handle it
>Over the last decade, federal officials say, the Zheng group mailed and shipped fentanyl and similar illicit chemicals to customers in more than 25 countries and 35 U.S. states. U.S. officials say the syndicate’s success, laid bare in a recent federal indictment[1], partly helps explain America’s skyrocketing death toll from drug overdoses. [2]
[1]https://www.justice.gov/opa/pr/two-chinese-nationals-charged... [2]http://www.latimes.com/politics/la-na-pol-china-fentanyl-201...
FOSTA has slaughtered many avenues of sourcing research chemicals. It is significantly more difficult to get them from a reliable source then it was this time last year. While this doesn't stop anyone sufficiently determined, it's harder to get a source of say fentanyl or U-47770 to cut with.
The US has been cracking down on producers of these in China, and many chinese or US based resellers have either ceased to exist or changed their operation (US seems to be heavily targeting opioids, China seems to be going after ketamine and analogs) . In addition the Darknet Markets have taken a big hit from Operation Bayonet. It's not to say that DNMs or their vendors or customers are gone, just they're finding it harder to regroup. Though there have been a number of high profile busts from the data of Operation Bayonet
This applies to more then just opioids though. Other drugs with overdose potential, like stimulants are just harder to get a hold of. Most US domestic sellers seem to focus on benzodiazepine analogs.
We'll see how long this lasts though, I doubt that whole scene is truly gone but it might just be in hibernation for a bit.
At a certain point people just stop buying drugs unless they're heavily addicted. The thing about research chems is that the ones that tended to stick around dose in the sub 50mg range. The cost per dose is still low since they're produced in multikg batches, resold in fraction to multi gram increments.
Spend a few hundred (even after losing a few shipments) and you can still easily make it back with one good shipment getting through.
Honestly, I think that the bombs getting sent to government officials is going to hurt things for them more than shipping costs would.
we'll see what the future holds though.
They currently have greatly stepped up their screening game though, mostly due to fentanyl. But that doesn't mean you have to ship straight to the US in bulk. A common route for fake pressed xanax was alprazolam powder to canada where it was pressed and either reshipped or smuggled into the US.
FOSTA was the "Fight Online Sex Trafficking Act," and the bill seemed solely focused on that topic. I'm also not seeing any other bill that would obviously lead to that happening, but I only looked at the titles.
Here's the announcement of Reddit banning said subs along with many others: https://www.reddit.com/r/announcements/comments/863xcj/new_a...
However China has been cracking down on it (and analogs like Deschloroketamine).
https://www.vice.com/en_us/article/vdxqk4/why-is-the-chinese...
And the list of people who died due to ketamine related things: https://erowid.org/chemicals/ketamine/ketamine_death.shtml
The latter is a rather predictable list of people dying while doing stupid things on ketamine and/or mixing it with depressants
I understand why people use drugs like heroin and fentanyl, but why methamphetamine? Why do they not just use Adderall or pure amphetamine? What is the gain? Amphetamine and Adderall in particular are not neurotoxic at normal doses, and are very safe if used responsibly. Methamphetamine seems to be inherently neurotoxic. Why risk your health when amphetamines and Adderall are just as good?
People do combine heroin and cocaine/heroin and meth, but the issues with cocaine and meth absolutely do not come from them being laced with heroin.
But PCP-laced pot? Never, and I can understand that someone isn't going to sprinkle free value-add on there. Cocaine will be laced with baking soda to increase profits, not more pricey drugs. I just never did figure out where people got that idea. Sure, sounds like heroin is getting cut with fentanyl (again, profits). But crack will get you plenty high, and addicted, on its own; there's no need for additives.
http://www.cph.org.uk/wp-content/uploads/2012/08/cut-a-guide...
For cocaine and crack cocaine, lidocaine is one common adulterant, sugars are another.
The thing about methamphetamine is that from what I understand it is neurotoxic at normal doses, and you have a much safer drug that's not going to be much more expensive available to purchase.
Uh, we give it to old people in dosages around 1/80 of a normal user's high. I forget exactly what for.
Around here (Australia) there is a huge difference in price, cocaine is hugely expensive and meth can be cheaper than legal cigarettes. I've heard of cocaine being much cheaper in the US but maybe that's regional? I think there are also supply issues, something that can be produced in a home lab is going to be around much more consistently.
The phenomenon is called the "iron law of prohibition" [0]:
The iron law of prohibition is a term
coined by Richard Cowan in 1986 which
posits that as law enforcement becomes
more intense, the potency of prohibited
substances increases. Cowan put it this
way: "the harder the enforcement, the
harder the drugs."
This law is an application of the Alchian–
Allen effect; Libertarian judge James P.
Gray calls the law the "cardinal rule of
prohibition", and notes that is a powerful
tool for the legalization of drugs.
It is based on the premise that when drugs
or alcohol are prohibited, they will be
produced in black markets in more
concentrated and powerful forms, because
these more potent forms offer better
efficiency in the business model—they take
up less space in storage, less weight in
transportation, and they sell for more
money. Economist Mark Thornton writes that
the iron law of prohibition undermines the
argument in favor of prohibition, because
the higher potency forms are less safe for
the consumer.
I learned this term from Johann Hari's book, Chasing the Scream: The First and Last Days of the War on Drugs [1].The "epidemic" of opioid overdose deaths would be ended instantly by giving the addicts all the pure heroin they need. ("I think I've mentioned this here before... uhm, 'Switzerland'..., found it").
A response to my comment [2] said "drug overdose deaths fell by about two thirds between 1995 (Heroin prescriptions started in about 1994) and 2012:" [3].
Meth amphetamine is basically an anti-depressant - people don't need even Adderall, they need safe anti-depressants (!SSRI)[4], and help finding stability [5].
[0] https://en.wikipedia.org/wiki/Iron_law_of_prohibition
[1] http://chasingthescream.com/
[2] https://news.ycombinator.com/item?id=14782416
[3] https://news.ycombinator.com/item?id=14783800
[4] https://news.ycombinator.com/item?id=18211048 (my comment about coca leaf's anti-depressant effects. Amphetamines are somewhat similar.)
[5] https://news.ycombinator.com/item?id=17997852
(edit: added [5], moved [4] to after "!SSRI") (Edit2: moved all the references [] from inline to the bottom of the comment.)
Of course, you had to secretly store potent enough alcohol, (potent enough to easily hide in quantity) and consume it quickly, to limit the likelihood of being found drinking in the dorms.
So, everyone bought 20oz soda bottles from the vending machines, knew their personal taste/tolerance in terms of how much soda to consume from the bottle, before filling it back up with their choice of rum or vodka, to be consumed quickly before departing for the evening.
"Economist Mark Thornton writes that
the iron law of prohibition undermines the
argument in favor of prohibition, because
the higher potency forms are less safe for
the consumer. "
Except the US govt hasn't cared about saving people who they deem breaking the law.In fact, they've helped kill people doing so. http://time.com/3665643/deadly-drinking/
With proper dosage and pure uncut drugs most addictions won't ruin the user's life unless of course they have to spend all their money on drugs because they cost so much. This leads to people becoming drug dealers to finance their habits. They start cutting the drugs with cement dust or other shit that is going to ruin the health of drug users downstream and smoke the drug for free.
Methamphetamine is more potent because it more easily crosses the blood brain barrier, but the effects are almost identical. It's also prescribed for ADHD, i.e. Desoxyn.
This has been my experience too. I don't think I could tell them apart if I was drugged with an equivalent dose and not told which was which. I think the appeal behind meth is mainly the better value, its ability to be smoked, and the difficulty in adulterating it (since it is typically sold in crystalline form, whereas amphetamine is often sold as a powder or paste).
Some people would like to have a little bit of legal amphetamine every now and again. Some people just want to get off their fucking gourd. At the moment it's hard to tell the two groups apart until they start using.
It seems like the young folks who try meth do it because they know someone attractive or otherwise fun to be around who is doing it. It is my completely uneducated guess that the first person to get addicted to meth, had it perscribed by a medical doctor.
Also as someone who dabbled with them and who had lots of friends who were like really into it, I saw the negative consequences first hand, but they’re subtle and take quite a bit of time to manifest. By the time it becomes obvious to you that there’s a problem, most of your non drug using friends have known for a while. But of course you don’t really hang out with your drug using friends any more.
It’s not the immediate horror show you’d expect from the movies or from watching Cops. You only see the worst of the worst. For every drug casualty you’ve met, there are probably dozens of people who do the casually for a few years, maintain jobs and relationships, get bored and then quit. That was at least the case for most of the people i went to raves with back in the day. Almost all of them settled down with families and careers and very few of them had trouble quitting.
I don’t recommend doing any of those things, I just think that people have a skewed idea of what it’s like.
Adderall is a combination of two amphetamines; dextroamphetamine and levoamphetamine. If you don't react well to Adderall, the next step is to try the constituent amphetamines separately. Dextroamphetamine is widely available by itself; levoamphetamine, until recently, was not. Fortunately, a close analogue to levoamphetamine is Desoxyn, which is just methamphetamine. Medicinal methamphetamine is legal in the United States.
Desoxyn, like Adderall, is a controlled substance kept in safes in pharmacies, and so it's a lot easier for your average junkie to settle for Uncle Jethro's crystal meth than to try to get his hands on real pharmaceutical-grade amphetamines, whether that's Desoxyn or Adderall, just like it's easier for your average junkie to get black tar heroin than to get Oxycodone.
> “The states that have been comprehensive and have gone after evidence-based methods are seeing the declines,” said Brandon Marshall, a Brown University epidemiologist.
A good friend of mine is a cop in Massachusetts. He carries Narcan.
Without looking up data right now: yes
edit: whoever claimed my comment is inaccurate should look at the stats for Naxolene usage on opioid users (https://www.health.ny.gov/statistics/opioid/data/pdf/nys_jul...). In one (1) county, they administered Naxolene to over 6,000 users. With that information, arguing there is no correlation between the wide spread availability of reversal drugs and the drop in deaths is just.. wrong.
From a creationist standpoint all people are equally likely to become addicted so you can use economic/cultural data as a proxy for susceptibility, however in the real evolutionary based world we have been brutally selecting for non addiction susceptible genetics and small scale culture for a long time, so at some point you'd expect a crash in addiction rates.
Something like cig smoking can't be bred out because the addicts die horribly in their 60s long after reproducing, but every teenage heroin overdose for the last couple decades is a permanent culling of the herd of people who can't handle their chemicals responsibly.
From a cultural standpoint I'm old enough that "Heroin just is not something our people do" works pretty well until it doesn't anymore, its interesting the study quotes seem to imply a grasp at any straw other than making heroin culturally unacceptable again, which ironically is probably the only thing that will work long term.
The issue is that drugs tend to be available and encouraged for rockers and actors.
Heroin, in particular, seems to have an unnatural appeal to guitarists and rockers and has claimed way more than it's fair share of them.
I really wish we would legalize some of these drugs even if we still keep them behind a prescription. Legalizing the drugs would certainly help as then the dosages would be controlled.
I'd guess it's a combination of many different factors.
I think (without bothering to do any research to source my claim beyond my personal experience as a paramedic, and the sources available in the article) that the widespread availability of Naloxone (and other harm reduction based policies) are far more likely to be the cause of the decrease.
Suppose that "susceptibility to opioid abuse" is a trait that's distributed throughout the population; some people are very susceptible, and some people are not very susceptible, but there's still an independent, individual factor that is separate from e.g. cultural/economic/social angst/uncertainty/etc., the availability of opioids, and so forth.
When there is a breakthrough in one of these external social factors--either opioids become a lot cheaper and more available, people slip into greater levels of despair, whatever--more people are going to abuse opioids. Fair enough. But not everyone is equally likely to abuse opioids even given the exact same circumstances, so most of this increase in opioid abuse will be concentrated in the chunk of the population that was more susceptible to it all along.
Once the opioid epidemic goes on for a few years, the people most likely to abuse opioids--and, for that matter, the people most likely to die from opioid abuse--will die. And so, if the underlying social causes of opioid abuse stay the same, you're going to see fewer opioid deaths, because the people who would have died already have.
Since this isn't necessarily a genetic trait, we probably wouldn't see this effect persist on the order of generations, but on the order of months to years there's definitely a survivor bias, so to speak.
There isn't necessarily any moral judgment in here, either. I mean, there can be, if you're a jerk about it, but the math itself doesn't work out any differently for "susceptibility to opioid addiction" than it does for "susceptibility to flu", and so if there's an epidemic of either one of those, odds are that, barring intervention, the epidemic is going to kill whoever it's going to kill and then move on. (This isn't cause for complacency, either! Some epidemics can kill huge supermajorities of the population if you just let them play themselves out, which is the true story of how the West[ern Hemisphere] was won.)
What's the "career path" of an addict? How many years before they are likely to overdose? Does that coincide with economic struggles of the recent years, military returning and suffering from PTSD? It might take drug addicts take more time to "progress" on their career than it does take new, deadlier drugs to kill them off. It sounds harsh, I know, but it's a possibility.
I sincerely hope the fall is due to less fentanyl being imported and parts of the darknet shutdown (I like how the netherland police once took over a darknet market).
In reality these drugs coming in from foreign countries should be treated as an act of war, we've already lost significantly more Americans to this epidemic than Vietnam, the long term economic cost is probably in the hundreds of billions. If another country did that kind of damage via bombing we would retaliate, but these deaths from drugs don't have a big enough emotional impact to get citizens angry
Clearly this is the fault of those nameless multi-national corporations who are gleefully clasping their hands while laughing madly.
Obviously these drug addicts having major problems and injecting themselves with illegally acquired, addictive drugs is exactly the same as bombing innocent people, and we should retaliate by having the marines storm the lobby of Pfizer.
The initial addiction though is due to doctor's and drug companies. There's plenty of evidence of drug companies pushing doctors to prescribe these drugs when they really aren't needed. Fine the companies, arrest the doctors and executives who push this stuff in the name of profit.
As for government, if you think the average congressmen cares about long term tax revenue vs that sweet pharma lobby money today, you're naive.
https://www.statnews.com/wp-content/uploads/2018/10/CDC-Over...
2016: 246-194 Republican
2014: 247-188 Republican
2012: 234-201 Republican
Six year incumbency.
2016: 52-46 Republican
2014: 54-44 Republican
2012: 53-45 Republican
2010: 51-47 Republican
8 years incumbency
Second, this isn’t a political football. This is something that every American can look at and agree that we need to be bringing powerful tools (regulatory, legal, policy, aid, EMS, hospital, pharmacy, education, volunteer, etc.) in a concerted and coordinated effort to fix this.
Third, any efforts are obviously going to take time to show up in the death rate, but even if we are turning a corner will need to be sustained across administrations.
One could sensibly make the argument that the root of the problem is the carving out of the middle class and manufacturing base of the country that occurred solidly during Obama’s years as a result of the push toward globalization. The massive economic improvement as a result of the tax cuts and deregulation since Trump’s election has helped get people whose jobs were “never coming back” to become gainfully employed again and motivated to face the hard fight against opioid dependence.
But in the end it’s just finger pointing / and falsely ascribing causation to correlation to try to score political points or demonize the “other side”.